Structure of PDB 8tlw Chain A Binding Site BS02
Receptor Information
>8tlw Chain A (length=438) Species:
9606,83333
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KIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQV
AATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYN
GKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFN
LQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIK
NKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTF
KGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLG
AVALKSYEEELAKDPRIAATMENAQKGEIMPNIPCMSAFWYAVRTAVINA
ASGRQTVDEALKDAQTAAADKCYLDELVELHRRLMTLRERHILQQIVNLI
EETGHFHITNTTFDFDLCSLDKTTVRKLQSYLETSGTS
Ligand information
Ligand ID
GLC
InChI
InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6+/m1/s1
InChIKey
WQZGKKKJIJFFOK-DVKNGEFBSA-N
SMILES
Software
SMILES
OpenEye OEToolkits 1.5.0
C(C1C(C(C(C(O1)O)O)O)O)O
OpenEye OEToolkits 1.5.0
C([C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)O)O)O)O)O
CACTVS 3.341
OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
CACTVS 3.341
OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O
ACDLabs 10.04
OC1C(O)C(OC(O)C1O)CO
Formula
C6 H12 O6
Name
alpha-D-glucopyranose;
alpha-D-glucose;
D-glucose;
glucose
ChEMBL
CHEMBL423707
DrugBank
ZINC
ZINC000003861213
PDB chain
8tlw Chain C Residue 1 [
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Receptor-Ligand Complex Structure
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PDB
8tlw
Structural studies of intrinsically disordered MLL-fusion protein AF9 in complex with peptidomimetic inhibitors.
Resolution
2.106 Å
Binding residue
(original residue number in PDB)
D15 K16 E112 Y156 W231
Binding residue
(residue number reindexed from 1)
D14 K15 E111 Y155 W230
Annotation score
4
Enzymatic activity
Enzyme Commision number
?
Gene Ontology
Molecular Function
GO:0005515
protein binding
GO:1901982
maltose binding
Biological Process
GO:0006974
DNA damage response
GO:0008643
carbohydrate transport
GO:0015768
maltose transport
GO:0034219
carbohydrate transmembrane transport
GO:0034289
detection of maltose stimulus
GO:0042956
maltodextrin transmembrane transport
GO:0060326
cell chemotaxis
Cellular Component
GO:0016020
membrane
GO:0030288
outer membrane-bounded periplasmic space
GO:0042597
periplasmic space
GO:0043190
ATP-binding cassette (ABC) transporter complex
GO:0055052
ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
GO:1990060
maltose transport complex
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Molecular Function
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Biological Process
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Cellular Component
External links
PDB
RCSB:8tlw
,
PDBe:8tlw
,
PDBj:8tlw
PDBsum
8tlw
PubMed
38747396
UniProt
P0AEX9
|MALE_ECOLI Maltose/maltodextrin-binding periplasmic protein (Gene Name=malE);
P42568
|AF9_HUMAN Protein AF-9 (Gene Name=MLLT3)
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