Structure of PDB 8tlq Chain A Binding Site BS02

Receptor Information
>8tlq Chain A (length=1283) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SDYFRIQLNNQDYYMSKPTFLDPSHGESLPLNQFSQVPNIRVFGALPTGH
QVLCHVHGILPYMFIKYDGQITDTSTLRHQRCAQVHKTLEVKIRASFKKL
GNLNFVADVSVVKGIPFYGYHVGWNLFYKISLLNPSCLSRISELIRDGKI
FGKKFEIYESHIPYLLQWTADFNLFGCSWINVDRCYFRSPVLNSILDIDK
LTINDDLQLLLDRFCDFKCNVLSRRDFPRVGNGLIEIDILPQFIKNREKL
QHRDIHHDFLEKLGDIKPYVSSARDMINELTMQREELSLKEYKEPPETKR
HVHQWQSSGEFEAFYKKAQHKTSTFDGQIPNFENFIDKNQKFSAINTPYE
ALPQLWPRLPGLRYGKRAFVYGEPPFGYQDILNKLEDEGFPKIDYKDPFF
SNPVDLENKPYAYAGKRFEISSTHVSTRIPVQFGGETVSVYNKPTFDMFS
SWKYALKPPTYDAVQKWYNKVSSVHDSLTHLTLEIHANTRSDKIPDPAID
EVSMIIWCLEEETFPLDLDIAYEGIMIVHKASEDSTFPTKIQHCINEIPV
MFYESEFEMFEALTDLVLLLDPDILSGFEIHNFSWGYIIERCQKIHQFDI
VRELARVKCQIKLSDTWGYAHSSGIMITGRHMINIWRALRSDVNLTQYTI
ESAAFNILHKRLPHFSFESLTNMWNAKKSTTELKTVLNYWLSRAQINIQL
LRKQDYIARNIEQARLIGIDFHSVYYRGSQFKVESFLIRICKSESFILLS
PGKKDVRKQKALECVPLVMEPESAFYKSPLIVLDFQSLYPSIMIGYNYCY
STMIGRVREINLTENNLGVSKFSLPRNILALLKNDVTIAPNGVVYAKTSV
RKSTLSKMLTDILDVRVMIKKTMNEIGDDNTTLKRLLNNKQLALKLLANV
TYGYTSASFSGRMPCSDLADSIVQTGRETLEKAIDIIEKDETWNAKVVYG
DTDSLFVYLPGKTAIEAFSIGHAMAERVTQNNPKPIFLKFEKVYHPSILI
SKKRYVGFSYESPSQTLPIFDAKGIETVRRDGIPAQQKIIEKCIRLLFQT
KDLSKIKKYLQNEFFKIQIGKVSAQDFCFAKEVKLGAYKSEKTAPAGAVV
VKRRINEDHRAEPQYKERIPYLVVKGKQGQLLRERCVSPEEFLEGENLEL
DSEYYINKILIPPLDRLFNLIGINVGNWAQEICGEELKICSLCDDCLEKR
STTTLSFLIKKLKRQKEYQTLKTVCRTCSYRYTSDAGIENDHIASKCNSY
DCPVFYSRVKAERYLRDNQSVQREEALISLNDW
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8tlq Cryo-EM structure of the Rev1-Pol zeta holocomplex reveals the mechanism of their cooperativity in translesion DNA synthesis.
Resolution3.53 Å
Binding residue
(original residue number in PDB)		T807 W808 R918 G919 S920 Q921 G1094 F1100 S1101 K1193 R1195 R1324 R1357
Binding residue
(residue number reindexed from 1)		T616 W617 R727 G728 S729 Q730 G903 F909 S910 K1002 R1004 R1133 R1166
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0000724 double-strand break repair via homologous recombination
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006974 DNA damage response
GO:0019985 translesion synthesis
GO:0042276 error-prone translesion synthesis
GO:0070987 error-free translesion synthesis
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0016035 zeta DNA polymerase complex
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8tlq, PDBe:8tlq, PDBj:8tlq
PDBsum8tlq
PubMed38720088
UniProtP14284|DPOZ_YEAST DNA polymerase zeta catalytic subunit (Gene Name=REV3)

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