Structure of PDB 8tbx Chain A Binding Site BS02

Receptor Information
>8tbx Chain A (length=458) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GMAAFSEMGVMPEIAQAVEEMDWLLPTDIQAESIPLILGGGDVLMAAETG
SGKTGAFSIPVIQIVYETLKDQSGAPKALIVEPSRELAEQTLNNIKQFKK
YIDNPKLRELLIIGGVAARDQLSVLENGVDIVVGTPGRLDDLVSTGKLNL
SQVRFLVLDEADGLLSQGYSDFINRMHNQIPQVTSDGKRLQVIVCSATLH
SFDVKKLSEKIMHFPTWVDLSVPDTVHHVVVPVNPKTDRLWERLGKSHIR
TDDVHAKDNTRPGANSPEMWSEAIKILKGEYAVRAIKEHKMDQAIIFCRT
KIDCDNLEQYFIQQGGGPDKKGHQFSCVCLHGDRKPHERKQNLERFKKGD
VRFLICTDVAARGIDIHGVPYVINVTLPDEKQNYVHRIGRVGRAERMGLA
ISLVATEKEKVWYHVCSSRGKGCYNTRLKEDGGCTIWYNEMQLLSEIEEH
LNCTISQV
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8tbx Chain A Residue 703 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8tbx Crystal structure of human DDX1 helicase in complex with ADP
Resolution2.71 Å
Binding residue
(original residue number in PDB)		H629 C631 C638 C649
Binding residue
(residue number reindexed from 1)		H414 C416 C423 C434
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003724 RNA helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:8tbx, PDBe:8tbx, PDBj:8tbx
PDBsum8tbx
PubMed
UniProtQ92499|DDX1_HUMAN ATP-dependent RNA helicase DDX1 (Gene Name=DDX1)

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