Structure of PDB 8ta2 Chain A Binding Site BS02

Receptor Information
>8ta2 Chain A (length=460) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GEDWIFLVLLGLLMALVSWVMDYAIAACLQAQQWMSRGLNTSILLQYLAW
VTYPVVLITFSAGFTQILAPQAVGSGIPEMKTILRGVVLKEYLTLKTFIA
KVIGLTCALGSGMPLGKEGPFVHIASMCAALLSKFLSLFGGIYENESRNT
EMLAAACAVGVGCCFAAPIGGVLFSIEVTSTFFAVRNYWRGFFAATFSAF
IFRVLAVWNRALFKTRFRLDFPFDLQELPAFAVIGIASGFGGALFVYLNR
KIVQVMRKQKTINRFLMRKRLLFPALVTLLISTLTFPPGFGQFMAGQLSQ
KETLVTLFDNRTWVRQSTSQAWNPPRANVFLTLVIFILMKFWMSALATTI
PVPCGAFMPVFVIGAAFGRLVGESMAAWFPDGISTYRIVPGGYAVVGAAA
LAGAVTHTVSTAVIVFELTGQIAHILPVMIAVILANAVAQSLQPSLYDSI
IRIKKLPYLP
Ligand information
Ligand IDCL
InChIInChI=1S/ClH/h1H/p-1
InChIKeyVEXZGXHMUGYJMC-UHFFFAOYSA-M
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Cl-]
FormulaCl
NameCHLORIDE ION
ChEMBL
DrugBankDB14547
ZINC
PDB chain8ta2 Chain A Residue 602 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8ta2 Cryo-EM structures of the human CLC-2 voltage gated chloride channel reveal a closed conformational state and pore block by an N-terminal hairpin peptide
Resolution2.74 Å
Binding residue
(original residue number in PDB)		G203 M460
Binding residue
(residue number reindexed from 1)		G116 M358
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005247 voltage-gated chloride channel activity
Biological Process
GO:0006821 chloride transport
GO:0055085 transmembrane transport
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8ta2, PDBe:8ta2, PDBj:8ta2
PDBsum8ta2
PubMed38345841
UniProtP51788|CLCN2_HUMAN Chloride channel protein 2 (Gene Name=CLCN2)

[Back to BioLiP]