Structure of PDB 8t85 Chain A Binding Site BS02

Receptor Information
>8t85 Chain A (length=335) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QPLVGKQILIVEDEQVFRSLLDSWFSSLGATTVLAADGVDALELLGGFTP
DLMICDIAMPRMNGLKLLEHIRNRGDQTPVLVISATENMADIAKALRLGV
EDVLLKPVKDLNRLREMVFACLYPSMFNSRVEEEERLFRDWDAMVDNPAA
AAKLLQELQPPVQQVISHCRVNYRQLVAADKPGLVLDIAALSENDLAFYC
LDVTRAGHNGVLAALLLRALFNGLLQEQLAHQNQRLPELGALLKQVNHLL
RQANLPGQFPLLVGYYHRELKNLILVSAGLNATLNTGEHQVQISNGVPLG
TLGNAYLNQLSQRCDAWQCQIWGTGGRLRLMLSAE
Ligand information
Ligand IDBEF
InChIInChI=1S/Be.3FH/h;3*1H/q+2;;;/p-3
InChIKeyOGIAHMCCNXDTIE-UHFFFAOYSA-K
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0[Be-](F)(F)F
ACDLabs 10.04
CACTVS 3.341		F[Be-](F)F
FormulaBe F3
NameBERYLLIUM TRIFLUORIDE ION
ChEMBL
DrugBank
ZINC
PDB chain8t85 Chain A Residue 405 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8t85 Structure of phosphorylated-like RssB, the adaptor delivering sigma s to the ClpXP proteolytic machinery, reveals an interface switch for activation.
Resolution2.38 Å
Binding residue
(original residue number in PDB)		D58 I59 A60 S86 A87 K108
Binding residue
(residue number reindexed from 1)		D56 I57 A58 S84 A85 K106
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000156 phosphorelay response regulator activity
GO:0000976 transcription cis-regulatory region binding
GO:0005515 protein binding
GO:0016989 sigma factor antagonist activity
Biological Process
GO:0000160 phosphorelay signal transduction system
GO:0006355 regulation of DNA-templated transcription
GO:0010468 regulation of gene expression
GO:0031648 protein destabilization
GO:0045862 positive regulation of proteolysis
GO:0045892 negative regulation of DNA-templated transcription
Cellular Component
GO:0005829 cytosol
GO:0032993 protein-DNA complex
GO:1903865 sigma factor antagonist complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8t85, PDBe:8t85, PDBj:8t85
PDBsum8t85
PubMed37949227
UniProtP0AEV1|RSSB_ECOLI Regulator of RpoS (Gene Name=rssB)

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