Structure of PDB 8t5s Chain A Binding Site BS02

Receptor Information
>8t5s Chain A (length=693) Species: 6239 (Caenorhabditis elegans) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QLCLRNYQEELCQVALQGKNTIVTAPTGSGKTVIAANIIKEHFESRSSEG
KRFKALFMTPNSMILNQQAASISSYLDHVYHTQIIQGSDNVPTRNVIQSK
DLIVATPQMIVNLCNEHRNSLDSRLDQFFLSTFTIIFFDECHNTVKNSPY
SNIMREYHYLKNMGNMPEGHSLPQIIGLTASLGTGDKNDCLQVRNYIAGL
CASMDVKDLSIVKDNLEELRGYSPIVPDKVLLCERSTDGPIGMFTNRLTL
MMQEVEGLIRTALRNEHIGSFLDPPADKEHAGYQNWVCNQMNLVSGTSFR
ETGTRTIINEALDVLKECFCTLSYNINFHPEVALNYLKDEMEYRTPNFTV
NMIRIWERYHNQLVGTGSAENPMISKTVQYIVEQNLQRADSRTIIFVRTR
YEATILNKVLNSNEELLMLGIKSEWMSGLNKSTASSADISASKQKQMEKL
KMFADGEIRILVSTSVAEEGLDVPECSLVIKYNYATNEIAHVQRRGRGRA
LNSECVLITNSIALRDQESNNRDKESLMSETISLIQNSPAEFRKCVDEES
NKIWPRILREDTDKAQKIEEQINRNIVYKIICKKCEAILCTSKDIRSRNT
QYLVCDPGFWSLVRKTRTGSINCRRENCGLKLGQLIEVNTVDLPCLSALS
IVLLVEGTDKRIIVKKWKNILDKYFTPTEIRQLDVQTMRDADQ
Ligand information
>8t5s Chain B (length=30) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
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Receptor-Ligand Complex Structure
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PDB8t5s C. elegans Dicer acts with the RIG-I-like helicase DRH-1 and RDE-4 to cleave dsRNA
Resolution2.9 Å
Binding residue
(original residue number in PDB)		P349 N350 S351 G376 T395 Q397 Q593 C597 R707 T708 R709 G737 L738 N739 T742 T773 V775 R907 N908 E959 K987
Binding residue
(residue number reindexed from 1)		P60 N61 S62 G87 T106 Q108 Q284 C288 R398 T399 R400 G428 L429 N430 T433 T464 V466 R598 N599 E637 K665
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
Biological Process
GO:0035194 regulatory ncRNA-mediated post-transcriptional gene silencing
GO:0045087 innate immune response
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8t5s, PDBe:8t5s, PDBj:8t5s
PDBsum8t5s
PubMed38747717
UniProtG5EDI8

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