Structure of PDB 8szs Chain A Binding Site BS02

Receptor Information
>8szs Chain A (length=856) Species: 9685 (Felis catus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TVEPYKVNLSQDLEHQLQNVIQELNLEIVPPPEDPFLPVVLNLGKSQRQI
GVVPWSPPQSNWNPWTSSNIDEGPLAYATPEQISMDLKNELMYQLEQDHD
LQAILQERELLPVKKFESEILEAISQNSVIIIRGATGCGKTTQVPQFILD
DFIQNDRAAECNIVVTQPRRISAVSVAERVAYERGEEPGKSCGYSVRFES
VLPRPHASIMFCTVGVLLRKLEAGIRGISHVIVDEIHERDINTDFLLVVL
RDVVQAYPEVRIVLMSATIDTSMFCEYFFNCPIIEVYGRTYPVQEYFLED
CIQMTHFVPPANCNLICGDEYGPETRMSMAQLNEKETPFELIEALLKYIE
TLNVPGAVLVFLPGWNLIYTMQKHLEMNPHFGSHRYQILPLHSQIPREEQ
RKVFDPVPSGVTKVILSTNIAETSITINDVVYVIDSCKQKVKLFTAHNNM
TNYATVWASKTNLEQRKGRAGRVRPGFCFHLCSRARFERLETHMTPEMFR
TPLHEIALSIKLLRLGGIGQFLAKAIEPPPLDAVIEAEHTLRELDALDAN
DELTPLGRILAKLPIEPRFGKMMIMGCIFYVGDAVCTISAATCFPEPFIS
EGKRLGYVHRNFAGNRFSDHVALLSVFQAWDDARMGGEEAEIRFCEHKRL
NMATLRMTWEAKVQLKEILINSGFPEDCLLTQVFTNTGPDNNLDVVISLL
AFGVYPNVCYHKEKRKILTTEGRNALIHKSSVNCPFSSQDMKYPSPFFVF
GEKIRTRAISAKGMTLVTPLQLLLFASKKVQSDGQIVLVDDWIRLQISHE
AAACITALRAAMEALVVEVTKQPNIISQLDPVNEHMLNMIRQISRPSAAG
INLMID
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain8szs Chain A Residue 1302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8szs Development of Assays to Support Identification and Characterization of Modulators of DExH-Box Helicase DHX9.
Resolution2.38 Å
Binding residue
(original residue number in PDB)		T419 E513
Binding residue
(residue number reindexed from 1)		T141 E235
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003725 double-stranded RNA binding
GO:0005524 ATP binding
GO:0033679 3'-5' DNA/RNA helicase activity

View graph for
Molecular Function
External links
PDB RCSB:8szs, PDBe:8szs, PDBj:8szs
PDBsum8szs
PubMed37625785
UniProtM3WPI7

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