Structure of PDB 8szp Chain A Binding Site BS02

Receptor Information
>8szp Chain A (length=855) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EPYKVNLSQDLEHQLQNIIQELNLEILPPPEDPSVPVALNIGKPSQRQNQ
VGVVPWSPPQSNWNPWTSSNIDEGPLAFATPEQISMDLKNELMYQLEQDH
DLQAILQERELLPVKKFESEILEAISQNSVVIIRGATGCGKTTQVPQFIL
DDFIQNDRAAECNIVVTQPRRISAVSVAERVAFERGEEPGKSCGYSVRFE
SILPRPHASIMFCTVGVLLRKLEAGIRGISHVIVDEIHERDINTDFLLVV
LRDVVQAYPEVRIVLMSATIDTSMFCEYFFNCPIIEVYGRTYPVQEYFLE
DCIQMTHFVPPPDANCNLICGDEYGPETRLSMSQLNEKETPFELIEALLK
YIETLNVPGAVLVFLPGWNLIYTMQKHLEMNPHFGSHRYQILPLHSQIPR
EEQRKVFDPVPVGVTKVILSTNIAETSITINDVVYVIDSCKQKVKLFTAN
YATVWASKTNLEQRKGRAGRVRPGFCFHLCSRARFERLETHMTPEMFRTP
LHEIALSIKLLRLGGIGQFLAKAIEPPPLDAVIEAEHTLRELDALDANDE
LTPLGRILAKLPIEPRFGKMMIMGCIFYVGDAICTIAAATCFPEPFINEG
KRLGYIHRNFAGNRFSDHVALLSVFQAWDDARMGGEEAEIRFCEHKRLNM
ATLRMTWEAKVQLKEILINSGFPEDCLLTQVFTNTGPDNNLDVVISLLAF
GVYPNVCYHKEKRKILTTEGRNALIHKSSVNCPFSSQDMKYPSPFFVFGE
KIRTRAISAKGMTLVTPLQLLLFASKKVQSDGQIVLVDDWIKLQISHEAA
ACITGLRAAMEALVVEVTKQPAIISQLDPVNERMLNMIRQISRPSAAGIN
LMIDY
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain8szp Chain A Residue 1302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8szp Crystal structures of DExH-box RNA helicase DHX9
Resolution2.62 Å
Binding residue
(original residue number in PDB)		T418 E512
Binding residue
(residue number reindexed from 1)		T142 E236
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003725 double-stranded RNA binding
GO:0005524 ATP binding
GO:0033679 3'-5' DNA/RNA helicase activity

View graph for
Molecular Function
External links
PDB RCSB:8szp, PDBe:8szp, PDBj:8szp
PDBsum8szp
PubMed37860960
UniProtQ08211|DHX9_HUMAN ATP-dependent RNA helicase A (Gene Name=DHX9)

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