Structure of PDB 8swn Chain A Binding Site BS02

Receptor Information
>8swn Chain A (length=1135) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VLPEDRSQHLGEELQGYWDQEVLRAEKDAREPSLTKAIIKCYWKSYVVLG
IFTLIEESTRVVQPIILGKIIGYFENYDPSDSAALYEAHGYAGVLSACTL
VLAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNSAMGKTTTGQIVN
LLSNDVNKFDQVTIFLHFLWAGPLQAIVVTALLWMEIGISCLAGMAVLII
LLPLQSCIGKLFSSLRSKTAAFTDTRIRTMNEVITGIRIIKMYAWEKSFA
DLITNLRRKEISKILRSSYLRGMNLASFFVASKIIVFVTFTTYVFLGNVI
TASRVFVAVSLYGAVRLTVTLFFPSAVEKVSEAFVSIRRIKNFLLLDEIM
IVNVQDFTAFWDKASDTPTLQSLSFTVRPGELLAVVGPVGAGKSSLLSAV
LGELPPNQGQVSVHGRIAYVSQQPWVFSGTVRSNILFGKKYEKERYEKVI
KACALKKDLQLLEDGDLTMIGDRGTTLSGGQKARVNLARAVYQDADIYLL
DDPLSAVDAEVSRHLFELCICQALHEKIRILVTHQLQYLKAASQILILKD
GQMVQKGVGFKAYKNYFTAGAHWFIIIFLILVNLAAQVSYILQDWWLSYW
ANQQSALNTEKLDLNWYLGIYSGLTASTVLFGIVRSLLVFFVLVSSSQTL
HNQMFESILRAPVLFFDRNPIGRILNRFSKDIGHMDDLLPLTYLDFIQTF
LQVIGVVGVAVAVIPWIAIPLVPLGIVFFVLRRYFPVFSHLSSSLQGLWT
IRAYKAEQRFQELFDSHQDLHSEAWFLFLTTSRWFAVRLDAICAVFVIVV
AFGSLILAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVERV
IEYTDLEKEAPWEYQKRPLPSWPHEGVIIFDNVNFSYSLDGPLVLKHLTA
LIKSKEKVGIVGRTGAGKSSLIAALFRLSEPEGKIWIDKILTTEIGLHDL
RKKMSIIPQEPVLFTGTMRKNLDPFNEHSDEELWNALEEVQLKEAIEDLP
GKMDTELAESGSNFSVGQRQLVCLARAILRKNRILIIDQATANVDPRTDE
LIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQ
NRDSLFYKMVQQLGKAEAAALTETAKQVYFKRNYP
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain8swn Chain A Residue 1402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8swn Structural basis of prostaglandin efflux by MRP4.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		S452 Q480
Binding residue
(residue number reindexed from 1)		S394 Q422
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0042626 ATPase-coupled transmembrane transporter activity
GO:0140359 ABC-type transporter activity
Biological Process
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8swn, PDBe:8swn, PDBj:8swn
PDBsum8swn
PubMed38216659
UniProtF1MUC1

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