Structure of PDB 8swc Chain A Binding Site BS02

Receptor Information
>8swc Chain A (length=149) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DFVVVYTDGCCSSNGRRRPRAGIGVYWGPGHPLNVGIRLPGRQTNQRAEI
HAACKAIEQAKTQNINKLVLYTNSMFTINGITNWVQGWKKNGWKTSAGKE
VINKEDFVALERLTQGMDIQWMHVPGHSGFIGNEEADRLAREGAKQSED
Ligand information
>8swc Chain C (length=20) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ccucactcacccactcgcca
....................
Receptor-Ligand Complex Structure
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PDB8swc Crystal structure of RNase H/RNA/PO-ASO complex at an atomic level
Resolution2.68 Å
Binding residue
(original residue number in PDB)		N151 G152 T181 N182 Q183 F213 W221 W225 T232 S233 V238 I239 N240
Binding residue
(residue number reindexed from 1)		N14 G15 T44 N45 Q46 F76 W84 W88 T95 S96 V101 I102 N103
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004523 RNA-DNA hybrid ribonuclease activity
GO:0004540 RNA nuclease activity
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006401 RNA catabolic process
GO:0043137 DNA replication, removal of RNA primer
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion

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Biological Process
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Cellular Component
External links
PDB RCSB:8swc, PDBe:8swc, PDBj:8swc
PDBsum8swc
PubMed
UniProtO60930|RNH1_HUMAN Ribonuclease H1 (Gene Name=RNASEH1)

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