Structure of PDB 8slg Chain A Binding Site BS02

Receptor Information

>8slg Chain A (length=429) Species: 1078020 (Mycolicibacterium thermoresistibile ATCC 19527)

AHHHHASIIDTVANLAKRRGFVYQSGEIYGGTRSAWDYGPLGVELKENIK
RQWWKSMVTAREDVVGIDTSIILPREVWVASGHVDVFHDPLVECLNCHRR
HRQVCPDCGTWTEPREFNMMLKTYLGPIESDEGLHYLRPETAQGIFTNFA
NVVTTARKKPPFGIAQTGKSFRNEITPGNFIFRTREFEQMEMEFFVEPST
AKEWHQYWIDTRLQWYVDLGIDRDNLRLYEHPPEKLSHYAERTVDIEYKY
GFAGDPWGELEGIANRTDFDLSTHSKHSGVDLSYYDQATDTRYVPYVIEP
AAGLTRSLMAFLIDAYSEDEKRTVLRFDPRLAPVKVAVLPLSRHADLSPK
ARDLAAELRQHWNVEFDDAGAIGRRYRRQDEVGTPYCVTVDFDSLEDNAV
TVRERDSMAQERISIDQVTDYLAVRLKGC

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 8slg Chain A Residue 502

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8slg Crystal Structure of Glycine tRNA ligase from Mycobacterium thermoresistibile (glycyl adenylate bound)
• Resolution: 1.95 Å
• Binding residue (original residue number in PDB): C90 C125 C128
• Binding residue (residue number reindexed from 1): C94 C105 C108
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 6.1.1.14: glycine--tRNA ligase.

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0004812 aminoacyl-tRNA ligase activity
• GO:0004820 glycine-tRNA ligase activity
• GO:0005524 ATP binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006412 translation
• GO:0006418 tRNA aminoacylation for protein translation
• GO:0006426 glycyl-tRNA aminoacylation

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:8slg, PDBe:8slg, PDBj:8slg
• PDBsum: 8slg
• UniProt: G7CIG9