Structure of PDB 8sl1 Chain A Binding Site BS02

Receptor Information
>8sl1 Chain A (length=843) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GLPILYFSGRRERLLLRPEVLAEIPREAFTVEAWVKPEGGQNNPAIIAGV
FDNCSHTVSDKGWALGIRSGKDKGKRDARFFFSLCTDRVKKATILISHSR
YQPGTWTHVAATYDGRHMALYVDGTQVASSLDQSGPLNSPFMASCRSLLL
GGDSSEDGHYFRGHLGTLVFWSTALPQSHFQHSSQHSSGEEEATDLVLTA
SFEPVNTEWVPFRDEKYPRLEVLQGFEPEPEILSPLQPPLCGQTVCDNVE
LISQYNGYWPLRGEKVIRYQVVNICDDIVSEEQIRLQHEALNEAFSRYNI
SWQLSVHQVHNSTLRHRVVLVNCEPSKIGNDHCDPECEHPLTGTCFDPDS
PKRAYMSVKELKEALQLNSTHFLNIYFASSVREDLAGAATWPWDKDAVTH
LGGIVLSPAYYGMPGHTDTMIHQVGHVLGLYHVFKGVSERESCNDPCKET
VPSMETGDLCADTAPTPKSELCREPEPTTRFPGAPFTNYMSYTDDNCTDN
FTPNQVARMHCYLDLVYQQWTESRKPTPIPIPPMVIGQTNKSLTIHWLPP
ISGVVYDRASGSLCGACTEDGTFRQYVHTASSRRVCDSSGYWTPEEAVGP
PDVDQPCEPSLQAWSPEVHLYHMNMTVPCPTEGCSLELLFQHPVQADTLT
LWVTSFFMESSQVLFDTEILLENKESVHLGPLDTFCDIPLTIKLHVDGKV
SGVKVYTFDERIEIDAALLTSQPHSPLCSGCRPVRYQVLRDPPFASGLPV
VVTHSHRKFTDVEVTPGQMYQYQVLAEAGGELGEASPPLNHIHGAPYCGD
GKVSERLGEECDDGDLVSGDGCSKVCELEEGFNCVGEPSLCYM
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain8sl1 Chain A Residue 1803 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8sl1 Cryo-EM structure of human PAPP-A2 and mechanism of substrate recognition
Resolution3.13 Å
Binding residue
(original residue number in PDB)		E679 D685 Q695 D798
Binding residue
(residue number reindexed from 1)		E596 D602 Q612 D715
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.24.-
Gene Ontology
Molecular Function
GO:0008237 metallopeptidase activity

View graph for
Molecular Function
External links
PDB RCSB:8sl1, PDBe:8sl1, PDBj:8sl1
PDBsum8sl1
PubMed37898658
UniProtQ9BXP8|PAPP2_HUMAN Pappalysin-2 (Gene Name=PAPPA2)

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