BioLiP

Receptor Information

>8sjy Chain A (length=220) Species: 9940 (Ovis aries) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SASFWRAIFAEFFATLFYVFFGLGASLRWAPGPLHVLQVALAFGLALATL
VQAVGHISGAHVNPAVTFAFLVGSQMSLLRAICYVVAQLLGAVAGAAVLY
SVTPPAVRGNLALNTLHPGVSVGQATIVEIFLTLQFVLCIFATYDERRNG
RLGSVALAVGFSLTLGHLFGMYYTGAGMNPARSFAPAILTRNFTNHWVYW
VGPVIGAGLGSLLYDFLLFP

Ligand ID

HWP

InChI

InChI=1S/C39H79N2O6P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-38(42)37(36-47-48(44,45)46-35-34-41(3,4)5)40-39(43)33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h30,32,37-38,42H,6-29,31,33-36H2,1-5H3,(H-,40,43,44,45)/b32-30+/t37-,38+/m0/s1

InChIKey

RWKUXQNLWDTSLO-GWQJGLRPSA-N

SMILES

Software	SMILES
OpenEye OEToolkits 2.0.7	CCCCCCCCCCCCCCCC(=O)N[C@@H](COP(=O)([O-])OCC[N+](C)(C)C)[C@@H](/C=C/CCCCCCCCCCCCC)O
CACTVS 3.385	CCCCCCCCCCCCCCCC(=O)N[CH](CO[P]([O-])(=O)OCC[N+](C)(C)C)[CH](O)C=CCCCCCCCCCCCCC
CACTVS 3.385	CCCCCCCCCCCCCCCC(=O)N[C@@H](CO[P]([O-])(=O)OCC[N+](C)(C)C)[C@H](O)\C=C\CCCCCCCCCCCCC
OpenEye OEToolkits 2.0.7	CCCCCCCCCCCCCCCC(=O)NC(COP(=O)([O-])OCC[N+](C)(C)C)C(C=CCCCCCCCCCCCCC)O

Formula

C39 H79 N2 O6 P

Name

[(E,2S,3R)-2-(hexadecanoylamino)-3-oxidanyl-octadec-4-enyl] 2-(trimethylazaniumyl)ethyl phosphate;
N-Palmitoylsphingomyelin

PDB chain

8sjy Chain A Residue 304 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8sjy Structure of aquaporin-0 arrays in sphingomyelin/cholesterol membranes and implications for lipid rafts
Resolution	2.35 Å
Binding residue (original residue number in PDB)	W10 F14 F17 L84 C88 V91
Binding residue (residue number reindexed from 1)	W5 F9 F12 L79 C83 V86
Annotation score	1

Enzyme Commision number

	Molecular Function
GO:0005212	structural constituent of eye lens
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0015250	water channel activity
GO:0015267	channel activity

	Biological Process
GO:0002088	lens development in camera-type eye
GO:0006833	water transport
GO:0007601	visual perception
GO:0045785	positive regulation of cell adhesion
GO:0051289	protein homotetramerization
GO:0055085	transmembrane transport
GO:1990349	gap junction-mediated intercellular transport

	Cellular Component
GO:0005783	endoplasmic reticulum
GO:0005886	plasma membrane
GO:0005921	gap junction
GO:0016020	membrane
GO:0016324	apical plasma membrane

PDB	RCSB:8sjy, PDBe:8sjy, PDBj:8sjy
PDBsum	8sjy
PubMed	39222068
UniProt	Q6J8I9\|MIP_SHEEP Lens fiber major intrinsic protein (Gene Name=MIP)

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Structure of PDB 8sjy Chain A Binding Site BS02