Structure of PDB 8s93 Chain A Binding Site BS02

Receptor Information
>8s93 Chain A (length=429) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MAAVILESIFLKRSQQKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSK
KGSIDVEKITCVETVIPEKNPPPERQIPRRGAERFPYPFQVVYDEGPLYV
FSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAM
GCQILENRGGGSGGGEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIR
MIREGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANG
CLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVN
DQGVVKVSDFGMTRYVLDDEYTSSTGSKFPVKWASPEVLMYSKFSSKSDI
WAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLPRPHLASERVYTIM
YSCWHEKADERPSFKILLSNILDVMDEES
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8s93 Chain A Residue 702 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8s93 Crystal structure of the PH-TH/kinase complex of Bruton's tyrosine kinase
Resolution2.1 Å
Binding residue
(original residue number in PDB)		H143 C155 C165
Binding residue
(residue number reindexed from 1)		H130 C142 C152
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0035556 intracellular signal transduction

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8s93, PDBe:8s93, PDBj:8s93
PDBsum8s93
PubMed38189455
UniProtP35991|BTK_MOUSE Tyrosine-protein kinase BTK (Gene Name=Btk)

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