Structure of PDB 8s3e Chain A Binding Site BS02

Receptor Information
>8s3e Chain A (length=902) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QRMWWAFLASSMVTFFGGLFIILLWRTLKYLWTVCCAEVGWMTSVKDWAG
VMISAQTLTGRVLVVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQI
DMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLNRS
WLGLRFLRALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAGF
IHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRL
FMVFFILGGLAMFASYVPEIIELIGNRKKYGGSYSAVSGRKHIVVCGHIT
LESVSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQ
GSVLNPHDLARVKIESADACLILANKYCADPDAEDASNIMRVISIKNYHP
KIRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFIAQSCLAQG
LSTMLANLFSMRSFIKIEEDTWQKYYLEGVSNEMYTEYLSSAFVGLSFPT
VCELCFVKLKLLMIAIEYKRILINPGNHLKIQEGTLGFFIASDAKEVKRA
FFYCKACHDVKKYDSTGMFHWCAPKEIEKVILTRSEAAMTVLSGHVVVCI
FGDVSSALIGLRNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLHNF
PKVSILPGTPLSRADLRAVNINLCDMCVILSANQNNIDDTSLQDKECILA
SLNIKSMQFDDITTGVNIPIITELVNDTNVQFLDQDDDDDPDTELYLTQP
FACGTAFAVSVLDSLMSATYFNDNILTLIRTLVTGGATPELEALIAEENA
LRGGYSTPQTLANRDRCRVAQLALLDGPFADLGDGGCYGDLFCKALKTYN
MLCFGIYRLRDAHLSTPSQCTKRYVITNPPYEFELVPTDLIFCLMQFDHN
AG
Ligand information
Ligand IDCLR
InChIInChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
InChIKeyHVYWMOMLDIMFJA-DPAQBDIFSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C
CACTVS 3.341CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
ACDLabs 10.04OC4CCC3(C(=CCC2C1C(C(C(C)CCCC(C)C)CC1)(C)CCC23)C4)C
OpenEye OEToolkits 1.5.0CC(C)CCC[C@@H](C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C
CACTVS 3.341CC(C)CCC[CH](C)[CH]1CC[CH]2[CH]3CC=C4C[CH](O)CC[C]4(C)[CH]3CC[C]12C
FormulaC27 H46 O
NameCHOLESTEROL
ChEMBLCHEMBL112570
DrugBankDB04540
ZINCZINC000003875383
PDB chain8s3e Chain A Residue 1202 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8s3e Cryo-EM structure of the Slo1 potassium channel with the auxiliary gamma 1 subunit suggests a mechanism for depolarization-independent activation.
Resolution2.39 Å
Binding residue
(original residue number in PDB)		F131 W246 Y274 W275 V278
Binding residue
(residue number reindexed from 1)		F79 W194 Y222 W223 V226
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005267 potassium channel activity
GO:0046872 metal ion binding
GO:0060072 large conductance calcium-activated potassium channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006813 potassium ion transport
GO:0042311 vasodilation
GO:0042391 regulation of membrane potential
GO:0055085 transmembrane transport
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0034702 monoatomic ion channel complex
GO:0045211 postsynaptic membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8s3e, PDBe:8s3e, PDBj:8s3e
PDBsum8s3e
PubMed38553946
UniProtQ9BG98|KCMA1_RABIT Calcium-activated potassium channel subunit alpha-1 (Gene Name=KCNMA1)

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