Structure of PDB 8rq9 Chain A Binding Site BS02

Receptor Information
>8rq9 Chain A (length=316) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSIQVIPVLPQVMMILVP
GQTLPLQLFHPQEVSMVRNLIQNDRTFAVLAYSNVQEREAEFGTTAEIYA
YREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPEAETLMD
RIKKQLREWDEDSLPSNPIDFSYWVAANLPIDDSLRIQLLKIDSAIQRLR
CELDIMNKCTSLCCKQCQETEITTKNEIFSLSREGPMAAYVNPHGYVHEI
LTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDM
SPQKFWGLTRSALIPT
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8rq9 Chain A Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8rq9 Design of a Cereblon construct for crystallographic and biophysical studies of protein degraders
Resolution2.91 Å
Binding residue
(original residue number in PDB)		C323 C391 C394
Binding residue
(residue number reindexed from 1)		C214 C282 C285
Annotation score4
External links
PDB RCSB:8rq9, PDBe:8rq9, PDBj:8rq9
PDBsum8rq9
PubMed
UniProtQ96SW2|CRBN_HUMAN Protein cereblon (Gene Name=CRBN)

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