Structure of PDB 8ro1 Chain A Binding Site BS02

Receptor Information
>8ro1 Chain A (length=1982) Species: 6239 (Caenorhabditis elegans) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DSILEEKSRKWKQLQGKRYSEKKKFGMSDTQKEEMPPEHVRKVIRDHGDM
TSRKYRHDKRVYLGALKYMPHAVLKLLENMPMPWEQIRDVKVLYHITGAI
TFVNDIPRVIEPVYMAQWGTMWIMMRREKRDRRHFKRMRFPPFDDEEPPL
DYADNILDVEPLEPIQMELDPEEDGAVAEWFYDHKPLATTRFVNGPTYRK
WAFSIPQMSTLYRLANQLLTDLVDDNYFYLFDMKSFFTAKALNVAIPGGP
KFEPLVKDLHTDEDWNEFNDINKVIIRAPIRTEYRIAFPFMYNNLISSLP
VQVSWYHTPSVVFIKTEDPDLPAFYYDPLINPIVLSNLKATEENLPEGEE
EDEWELPEDVRPIFEDVPLYTDNTANGLALLWAPRPFNLRSGRTRRAVDV
PLVKSWYREHCPAGMPVKVRVSYQKLLKVFVLNALKHRPPKPQKRRYLFR
SFKATKFFQTTTLDWVEAGLQVLRQGYNMLNLLIHRKNLNYLHLDYNFNL
KPVKTLTTKERKKSRFGNAFHLCREILRLTKLVVDAHVQYRLNNVDAYQL
ADGLQYIFAHVGQLTGMYRYKYKLMRQVRMCKDLKHLIYYRFNTGPVGKG
PGCGFWAPGWRVWLFFLRGITPLLERWLGNLLSRQFEGRHSKGVAKTVTK
QRVESHFDLELRAAVMHDILDMMPDGIKQNKARVILQHLSEAWRCWKANI
PWKVPGLPTPVENMILRYVKAKADWWTNSAHYNRERVRRGATVDKTVCKK
NLGRLTRLYLKSEQERQHNYLKDGPYISAEEAVAIYTTTVHWLESRRFSP
IPFPPLSYKHDTKLLILALERLKESYSVKNRLNQSQREELALIEQAYDNP
HEALSRIKRHMLTQRAFKEVGIEFMDLYTHLIPVYDIEPLEKVTDAYLDQ
YLWYEADKRRLFPAWVKPGDTEPPPLLTYKWCQGLNNLQDVWETSEGECN
VIMETKLEKIAEKMDLTLLNRLLRLIVDHNIADYMTSKNNVLINYKDMNH
TNSFGIIRGLQFASFIVQFYGLVLDLLVLGLRRASEIAGPPQCPNEFLQF
QDVATEIGHPIRLYCRYIDRVWIMFRFSADEARDLIQRYLTEHPDPNNEN
IVGYNNKKCWPRDARMRLMKHDVNLGRAVFWDIKNRLPRSITTVEWENSF
VSVYSKDNPNMLFDMSGFECRILPKCRTANEEFVHRDGVWNLQNEVTKER
TAQCFLKVDEESLSKFHNRIRQILMSSGSTTFTKIVNKWNTALIGLMTYF
REAVVNTQELLDLLVKCENKIQTRIKIGLNSKMPSRFPPVVFYTPKEIGG
LGMLSMGHVLIPQSDLRWMQQTEAGGVTHFRSLIPNLYRYIQPWEAEFVD
SVRVWAEYALKRQEANAQNRRLTLEDLDDSWDRGIPRINTLFQKDRHTLA
YDKGWRVRTEFKAYQILKQNPFWWTHQRHDGKLWNLNNYRTDMIQALGGV
EGILEHTLFRGTYFPTWEGLFWERASGFEESMKFKKLTNAQRSGLNQIPN
RRFTLWWSPTINRANVYVGFQVQLDLTGIFMHGKIPTLKISLIQIFRAHL
WQKIHESVVMDLCQVFDQELDALEIQTVQKETIHPRKSYKMNSSCADVLL
FAQYKWNVSRPSLMADSKDVMDNTTTQKYWLDVQLRWGDYDSHDVERYAR
AKFLDYTTDNMSIYPSPTGVLIAIDLAYNLYSAYGNWFPGMKPLIRQAMA
KIIKANPAFYVLRERIRKGLQLYSSENYGELFSNQIIWFVDDTNVYRVTI
HKTFEGNLTTKPINGAIFIFNPRTGQLFLKIIHTSVWAGQKRLSQLAKWK
TAEEVAALIRSLPVEEQPRQIIVTRKAMLDPLEVHLLDFPNIVIKGSELM
LPFQAIMKVEKFGDLILKATEPQMVLFNLYDDWLKTISSYTAFSRVVLIM
RGMHINPDKTKVILKPDKTTITEPHHIWPTLSDDDWIKVELALKDMILAD
YGKKNNVNVASLTQSEVRDIILGMEISAPSQQ
Ligand information
>8ro1 Chain 5 (length=111) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
acucugguuccucugcauuuaaccgugaaaaucuuucgccuuuuacuaaa
gauuuccgugcaaaggagcauacauugaguaaauuuuuggaguccccucg
agagagcggga
......<<<<<<.<<<<...........<<<<<<<<...........>>>
>>>>>...>>>>.>>>>>>.......................<<<<<<<.
...>>>.>>>>
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8ro1 Mechanism for the initiation of spliceosome disassembly.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		K40 G42 H87 I122 P212 T213 R215 K256 E269 L271 R401 R409 R411 R412 D415 P417 K420 N449 H453 R454 P456 K457 P458 Q459 K460 R461 R466 K469 Y586 K587 Y588 K589 Q593 R627 F631 F632 R634 G635 P638 L639 K666 V759 S1245 K1286 R1290 I1293
Binding residue
(residue number reindexed from 1)		K24 G26 H71 I106 P196 T197 R199 K240 E253 L255 R385 R393 R395 R396 D399 P401 K404 N433 H437 R438 P440 K441 P442 Q443 K444 R445 R450 K453 Y570 K571 Y572 K573 Q577 R611 F615 F616 R618 G619 P622 L623 K650 V743 S1229 K1270 R1274 I1277
External links
PDB RCSB:8ro1, PDBe:8ro1, PDBj:8ro1
PDBsum8ro1
PubMed38925148
UniProtP34369|PRP8_CAEEL Pre-mRNA-splicing factor 8 homolog (Gene Name=prp-8)

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