Structure of PDB 8r6w Chain A Binding Site BS02

Receptor Information
>8r6w Chain A (length=1974) Species: 992210 (SFTS virus AH12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MNLEVLCGRINVENGLSLGEPGLYDQIYDRPGLPDLDVTVDATGVTVDIG
AVPDSASQLGSSINAGLITIQLSEAYKINHDFTFSGLSKTTDRRLSEVFP
ITHDGSDGMTPAVIHTRLDGTIVVVEFSTTRSHNIGGLEAAYRTKIEKYR
DPISRRVDIMENPRVFFGVIVVSSGGVLSNMPLTQDEAEELMYRFCIANE
IYTKARSEELEAISRALSFFSLFEPNIERVEGTFPNSEIKMLEQFLSTPA
DVDFITKTLKAKEVEAYADLCDSHYLKPEKTIQERLEINRCEAIDKTQDL
LAGLHARSNKQTSLNRGTVKLPPWLPKPSSESIDIKTDSGFGSLMDHGAY
GELWAKCLLDVSLGNVEGVVSDPAKELDIAISDDPITYRRFKPALSSSAR
QEFSLQGVEGKKWKRMAANQKKEKESHETLSPFLDVEDIGDFLTFNNLLT
DSRYGDESIQRAVSILLEKASAMQDTELTHALNDSFKRNLSSNVVQWSLW
VSCLAQELASALKQHCRAGEFIIKKLKFWPIYVIIKPTKSSSHIFYSLGI
RKADVTRRLTGRVFSDTIDAGEWELTEFKSLKTCKLTNLVNLPCTMLNSI
AFWREKLGVAPWLVRKPCSELREQVGLTFLISLEDKSKTEEIITLTRYTQ
MEGFVSPPMLPKPQKMLGKLDGPLRTKLQVYLLRKHLDCMVRIASQPFSL
IPREGRVEWGGTFHAISGRSTNLENMVNSWYIGYYKNKEESTELNALGEM
YKKIVEMEEDKPSSPEFLGWGDTDSPKKHEFSRSFLRAACSSLEREIAQR
HGRQWKQNLEERVLREIGTKNILDLASMKATSNFSKDWELYSEVQTKEYH
RSKLLEKMATLIEKGVMWYIDAVGQAWKAVLDDGCMRICLFKKNQHGGLR
EIYVMDANARLVQFGVETMARCVCELSPHETVANPRLKNSIIENHGLKSA
RSLGPGSININSSNDAKKWNQGHYTTKLALVLCWFMPAKFHRFIWAAISM
FRRKKMMVDLRFLAHLSSKSESRSSDPFREAMTDAFHGNRDVSWMDKGRT
YIKTETGMMQGILHFTSSLLHSCVQSFYKSYFVSKLKEGYMGESISGVVD
VIEGSDDSAIMISIRPKSDMDEVRSRFFVANLLHSVKFLNPLFGIYSSEK
STVNTVYCVEYNSEFHFHRHLVRPTLRWIAASHQISETEALASRQEDYSN
LLTQCLEGGASFSLTYLIQCAQLLHHYMLLGLCLHPLFGTFMGMLISDPD
PALGFFLMDNPAFAGGAGFRFNLWRACKTTDLGRKYAYYFNEIQGKTKGD
EDYRALDATSGGTLSHSVMVYWGDRKKYQALLNRMGLPEDWVEQIDENPG
VLYRRAANKKELLLKLAEKVHSPGVTSSLSKGHVVPRVVAAGVYLLSRHC
FRFSTQKASLIKLLMMSSISAMKHGGSLNPNQERMLFPQAQEYDRVCTLL
EEVEHLTGKFVVRERNIVRSRIDLFQEPVDLRCKAEDLVSEVWFGLKRTK
LGPRLLKEEWDKLRASFAWLSTDPSETLRDGPFLSHVQFRNFIAHVDAKS
RSVRLLGAPVTTISQVVRMNFFPGFSLEAEESISILKHVLFMVLNGPYTE
EYKLEMIIEAFSTLVIPQPSEVIRKSRTMTLCLLSNYLSSRGGSILDQIE
RAQSGTLGGFSKPQKTFVRPGGGVGYKGKGVWTGVMEDTHVQILIDGDGT
SNWLEEIRLSSDARLYDVIESIRRLCDDLGINNRVASAYRGHCMVRLSGF
KIKPASRTDGCPVRIMNPDEVKMRVRGDILNLSVTIQEGRVMNILSYRPR
DTDISESAAAYLWSNRDLFSFGKKEPSCSWICLKTLDNWAWSHASVLLAN
DRKTQGIDNRAMGNIFRDCLEGSLRKQGLMRSKLIAVELSEGSLDIESIF
DGAPILWSAEVEEFGEGVVAVSYSSKYYHLTLMDQAAITMCAIMGKEGCR
GLLTEKRCMAAIREQVRPFLIFLQ
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8r6w Structural snapshots of phenuivirus cap-snatching and transcription
Resolution3.35 Å
Binding residue
(original residue number in PDB)		R318 K331 Q426 G427 E429 G430 K431 K434 K442 E443 K444 S446 H447 T449 K559 S562 H563 S600 K605 K656 R695 E763 N765 F1032 H1035 S1044 S1045 R1049
Binding residue
(residue number reindexed from 1)		R307 K320 Q406 G407 E409 G410 K411 K414 K422 E423 K424 S426 H427 T429 K539 S542 H543 S580 K585 K636 R675 E743 N745 F1012 H1015 S1024 S1025 R1029
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003968 RNA-dependent RNA polymerase activity
GO:0016740 transferase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0019079 viral genome replication
GO:0039694 viral RNA genome replication
Cellular Component
GO:0044165 host cell endoplasmic reticulum
GO:0044172 host cell endoplasmic reticulum-Golgi intermediate compartment
GO:0044177 host cell Golgi apparatus
GO:0044423 virion component

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8r6w, PDBe:8r6w, PDBj:8r6w
PDBsum8r6w
PubMed38709882
UniProtI0DF35|L_SFTS RNA-directed RNA polymerase L

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