Structure of PDB 8qh3 Chain A Binding Site BS02

Receptor Information
>8qh3 Chain A (length=1310) Species: 11602 (Hantaan virus 76-118) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YIPDYKGMEPIGANIEDLVDYSKDWLSRARNFSFFEVKGTAVFECFNSNE
ANHCQRYPMSRKPRNFLLIQCSLITSYKPATTLSDQIDSRRACSYILNLI
PDTPASYLIHDMAYRYINLTREDMINYYAPRIQFKQTQNVREPGTFKLTS
SMLRAESKAMLDLLNNQIESLNIASHIVQSESVSLITKILSDLELNIVLD
KFFQNETQKYLIDVLKKTTAWHIGHLIRDITESLIAHSGLKRSKYWSLHS
YNNGNVILFILPSKSLEVAGSFIRFITVFRIGPGLVDKDNLDTILIDGDS
QWGVSKVMSIDLNRLLALNIAFEKALIATATWFQYYTEDQGQFPLQYAIR
SVFANHFLLAICQKMKLCAIFDNLRYLIPAVTSLYSGFPSLIEKLFERPF
KSSLEVYIYYNIKSLLVALAQNVYPSFMSRIVYKHYRSLISEVTTCFFLF
EKGLHGNMNEEAKIHLETVEWALKFREKEEKYGESLVENGYMMWELRANA
ELAEQQLYCQDAIELAAIELNKVLATKSSVVANSILSKNWEEPYFSQTRN
ISLKGMSGQVQEDGHLSSSVTIIEAIRYLSNSRHNPSLLKLYEETREQKA
MARIVRKYQRTEADRGFFITTLPTRCRLEIIEDYYDAIAKNISEEYISYG
GEKKILAIQGALEKALRWASGESFIELSNHKFIRMKRKLMYVSADATKWS
PGDNSAKFRRFTSMLHNGLPNNKLKNCVIDALKQVYKTDFFMSRKLRNYI
DSMESLDPHIKQFLDFFPDGHHGEVKGNWLQGNLNKCSSLFGVAMSLLFK
QVWTNLFPELDCFFEFAHHSDDALFIYGYLEPVDDGTDWFLFVSQQIQAG
HLHWFSVNTEMWKSMFNLHEHILLLGSIKISPKKTTVSPTNAEFLSTFFE
GCAVSIPFVKILLGSLSDLPGLGYFDDLAAAQSRCVKALDLGASPQVAQL
AVALCTSKVERLYGTAPGMVNHPAAYLQVKHTDTPIPLGGNGAMSIMELA
TAGIGMSDKNLLKRALLGYSHKRQKSMLYILGLFKFLMKLSDETFQHERL
GQFSFIGKVQWKIFTPKSEFEFADMYTSKFLELWSSQHVTYDYIIPKGRD
NLLIYLVRKLNDPSIVTAMTMQSPLQLRFRMQAKQHMKVCRLDGEWVTFR
EVLAAANSFAENYSATSQDMDLFQTLTSCTFSKEYAWKDFLNGIHCDVIP
TKQVQRAKVARTFTSIPAVIGYKFAVTVEEMSDVLDTAKFPDSLSVDLKT
MKDGVYRELGLDISLPDVMKRIAPMLYKRVVIVQGNVEGTAEAICRYWLK
SMSLVKTIRV
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain8qh3 Chain A Residue 2201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8qh3 Structural characterization of the oligomerization of full-length Hantaan virus polymerase into symmetric dimers and hexamers.
Resolution2.81 Å
Binding residue
(original residue number in PDB)		A971 D1099
Binding residue
(residue number reindexed from 1)		A694 D822
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.1.-.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0004519 endonuclease activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0019079 viral genome replication
GO:0039689 negative stranded viral RNA replication
GO:0039694 viral RNA genome replication
GO:0039696 RNA-templated viral transcription
GO:0075526 cap snatching
Cellular Component
GO:0030430 host cell cytoplasm
GO:0044220 host cell perinuclear region of cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8qh3, PDBe:8qh3, PDBj:8qh3
PDBsum8qh3
PubMed38480734
UniProtP23456|L_HANTV RNA-directed RNA polymerase L (Gene Name=L)

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