Structure of PDB 8qbm Chain A Binding Site BS02

Receptor Information
>8qbm Chain A (length=309) Species: 469008 (Escherichia coli BL21(DE3)) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SAEYLNTFRLRNLGLPVMNNLHDMSKATRISVETLRLLIYTADFRYRIYT
VEKKGPEKRMRTIYQPSRELKALQGWVLRNILDKLSSSPFSIGFEKHQSI
LNNATPHIGANFILNIDLEDFFPSLTANKVFGVFHSLGYNRLISSVLTKI
CCYKNLLPQGAPSSPKLANLICSKLDYRIQGYAGSRGLIYTRYADDLTLS
AQSMKKVVKARDFLFSIIPSEGLVINSKKTCISGPRSQRKVTGLVISQEK
VGIGREKYKEIRAKIHHIFCGKSSEIEHVRGWLSFILSVDSKSHRRLITY
ISKLEKKYG
Ligand information
>8qbm Chain B (length=85) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gtcagaaaaaacgggtttcctggttggctcggagagcatcaggcgatgct
ctccgttccaacaaggaaaacagacagtaactcag
Receptor-Ligand Complex Structure
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PDB8qbm Retron-Eco1 assembles NAD + -hydrolyzing filaments that provide immunity against bacteriophages.
Resolution3.09 Å
Binding residue
(original residue number in PDB)		E35 R38 Y42 F46 R47 Y51 S69 R70 K73 I102 A129 N130 K131 F133 G134 S138 R143 S147 T150 K151 K156 K176 R180 G183 Y184 R188 Y195 A196 D197 D214 F215 I219 T244 H280 G283 W284 F287
Binding residue
(residue number reindexed from 1)		E33 R36 Y40 F44 R45 Y49 S67 R68 K71 I100 A127 N128 K129 F131 G132 S136 R141 S145 T148 K149 K154 K174 R178 G181 Y182 R186 Y193 A194 D195 D212 F213 I217 T242 H278 G281 W282 F285
Enzymatic activity
Enzyme Commision number 2.7.7.49: RNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003964 RNA-directed DNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006974 DNA damage response
GO:0051607 defense response to virus

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Molecular Function
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Biological Process
External links
PDB RCSB:8qbm, PDBe:8qbm, PDBj:8qbm
PDBsum8qbm
PubMed38788717
UniProtP23070|RT86_ECOLX Retron Ec86 reverse transcriptase (Gene Name=ret)

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