Structure of PDB 8q7q Chain A Binding Site BS02

Receptor Information
>8q7q Chain A (length=1645) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MSEEKLQEKARKWQQLQAKRYAEEDMPPEHVRKIIRDHKRVYLGALKYMP
HAVLKLLENMPMPWEQIRDVPVLYHITGAISFVNEIPWVIEPVYISQWGS
MWIMMRREKRDRFKRMRFPPFDDEEPPLDYADNILDVEPLEAIQLELDPE
EDAPVLDWFYDHQPLRDSRKYVNGSTYQRWQFTLPMMSTLYRLANQLLTD
LVDDNYFYLFDLKAFFTSKALNMAIPGGPKFEPLDEDWNEFNDINKIIIR
QPIRTEYKIAFPYLYNNLPHHVHLTWYHTPNVVFIKTEDPDLPAFYFDPL
INPISHREPLPDDDEEFELPEFVEPFLKDTPLYTDNTANGIALLWAPRPF
NLRSGRTRRALDIPLVKNWYREHCPAGQPVKVRVSYQKLLKYYVLNALKH
RPPKAQKKRYLFRSFKATKFFQSTKLDWVEVGLQVCRQGYNMLNLLIHRK
NLNYLHLDYNFNLKPVKTLTTKERKKSRFGNAFHLCREVLRLTKLVVDSH
VQYRLGNVDAFQLADGLQYIFAHVGQLTGMYRYKYKLMRQIRMCKDLKHL
IYYRFNTGPVGKGPGCGFWAAGWRVWLFFMRGITPLLERWLGNLLASHFD
LELRAAVMHDILDMMPEGIKQNKARTILQHLSEAWRCWKANIPWKVPGLP
TPIENMILRYVKAKADWWTNTAHYNRERIRRGATVDKTVCKKNLGRLTRL
YLKAEQERQHNYLKDGPYITAEEAVAVYTTTVHWLESRRFSPIPFPPLSY
KHDTKLLILALERLKEAYSVKSRLNQSQREELGLIEQAYDNPHEALSRIK
RHLLTQRAFKEVGIEFMDLYSHLVPVYDVEPLEKITDAYLDQYLWYEADK
RRLFPPWIKPADTEPPPLLVYKWCQGINNLQDVWETSEGECNVMLESRFE
KMYEKIDLTLLNRLLRLIVDHNIADYMTAKNNVVINYKDMNHTNSYGIIR
GLQFASFIVQYYGLVMDLLVLGLHRASEMAGPPQMPNDFLSFQDIATEAA
HPIRLFCRYIDRIHIFFRFTADEARDLIQRYLTEHPDPNNENIVGYNNKK
CWPRDARMRLMKHDVNLGRAVFWDIKNRLPRSVTTVQWENSFVSVYSKDN
PNLLFNMCGFECRILPKCRTSYEEFTHKDGVWNLQNEVTKERTAQCFLRV
DDESMQRFHNRVRQILMASGSTTFTKIVNKWNTALIGLMTYFREAVVNTQ
ELLDLLVKCENKIQTRIKIGLNSKMPSRFPPVVFYTPKELGGLGMLSMGH
VLIPQSDLRWSKQTDVGITHFRSQLIPNLYRYIQPWESEFIDSQRVWAEY
ALKRQEAIAQNRRLTLEDLEDSWDRGIPRINTLFQKDRHTLAYDKGWRVR
TDFKQYQVLKQNPFWWTHQRHDGKLWNLNNYRTDMIQALGGVEGILEHTL
FKGTYFPTWEGLFWEKNQIPNRRFTLWWSPTINRANVYVGFQVQLDLTGI
FMHGKIPTLKISLIQIFRAHLWQKIHESIVMDLCQVFDQELDALEIETVQ
KETIHPRKSYKMNSSCADILLFASYKWNVSRPSLLADSKDVMDSTTTQKY
WIDIQLRWGDYDSHDIERYARAKFLDYTTDNMSIYPSPTGVLIAIDLAYN
LHSAYGNWFPGSKPLIQQAMAKIMKANPALYVLRERIRKGLQLYS
Ligand information
>8q7q Chain B (length=28) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
PTGEVLSLVGKLEGTRMGDKAQRTKPQM
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8q7q Structural basis of human U5 snRNP late biogenesis and recycling.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		H1209 R1275 D1286 V1289 N1293 R1310 G1331 H1332 V1333 Y1369 R1370 Y1371 I1372 P1374 W1412 D1413 R1414 N1466 N1469
Binding residue
(residue number reindexed from 1)		H1127 R1193 D1204 V1207 N1211 R1228 G1249 H1250 V1251 Y1280 R1281 Y1282 I1283 P1285 W1323 D1324 R1325 N1377 N1380
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008237 metallopeptidase activity
GO:0017070 U6 snRNA binding
GO:0030619 U1 snRNA binding
GO:0030620 U2 snRNA binding
GO:0030623 U5 snRNA binding
GO:0070530 K63-linked polyubiquitin modification-dependent protein binding
GO:0097157 pre-mRNA intronic binding
GO:0140492 metal-dependent deubiquitinase activity
Biological Process
GO:0000244 spliceosomal tri-snRNP complex assembly
GO:0000375 RNA splicing, via transesterification reactions
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0071222 cellular response to lipopolysaccharide
GO:0071356 cellular response to tumor necrosis factor
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005682 U5 snRNP
GO:0016020 membrane
GO:0016607 nuclear speck
GO:0030532 small nuclear ribonucleoprotein complex
GO:0046540 U4/U6 x U5 tri-snRNP complex
GO:0071005 U2-type precatalytic spliceosome
GO:0071006 U2-type catalytic step 1 spliceosome
GO:0071007 U2-type catalytic step 2 spliceosome
GO:0071013 catalytic step 2 spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8q7q, PDBe:8q7q, PDBj:8q7q
PDBsum8q7q
PubMed38467876
UniProtQ6P2Q9|PRP8_HUMAN Pre-mRNA-processing-splicing factor 8 (Gene Name=PRPF8)

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