Structure of PDB 8q6g Chain A Binding Site BS02

Receptor Information
>8q6g Chain A (length=385) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EPVRLAPEREFIKSLMAIGKRLATLPTKEQKTQRLISELSLLNHKLPARV
WLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECENFDTTSVPAR
IPEEPWQEKVRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQ
LQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVSIHQVKKQSQLSLL
DYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDA
EGHIIHIDFGFILSSSPRNLGFETSAFKLTTEFVDVMGGLDGDMFNYYKM
LMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMT
EEQLQLLVEQMVDGSMRSITTKLYDGFQYLTNGIM
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain8q6g Chain A Residue 902 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8q6g Covalent targeting of non-cysteine residues in PI4KIII beta.
Resolution1.541 Å
Binding residue
(original residue number in PDB)		Q794 T797 N798 G799
Binding residue
(residue number reindexed from 1)		Q378 T381 N382 G383
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.1.67: 1-phosphatidylinositol 4-kinase.
Gene Ontology
Molecular Function
GO:0016301 kinase activity
Biological Process
GO:0046854 phosphatidylinositol phosphate biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8q6g, PDBe:8q6g, PDBj:8q6g
PDBsum8q6g
PubMed38033723
UniProtQ9UBF8|PI4KB_HUMAN Phosphatidylinositol 4-kinase beta (Gene Name=PI4KB)

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