Structure of PDB 8q63 Chain A Binding Site BS02

Receptor Information
>8q63 Chain A (length=915) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
INFFEIYNSLPTLEEKKAFESALNIFNQDRQKVLENRATEAARERWKHDF
EEAKARGDISIEKNLNVKLWKWYNEMLPLVKEEINHCRSLLSEKLSDKKG
LNKVDTNRLGYGPYLTLIDPGKMCVITILELLKLNSTGEGMRTARAVISV
GKAIEMEFRSEQVLKKILWPQSIRARIGSVLISMLIQVAKVSVQGVDPVT
KAKVHGEAPAFAHGYQYHNGSKLGVLKIHKTLIRQLNGERLIASVQPQLL
PMLVEPKPWVNWRSGGYHYTQSTLLRTKDSPEQVAYLKAASDNGDIDRVY
DGLNVLGRTPWTVNRKVFDVVSQVWNKGEGFLDIPGAQDEMVLPPAPPPS
ILRAWKLQVKTIANKFSSDRSNRCDTNYKLEIARAFLGEKLYFPHNLDFR
GRAYPLSPHFNHLGNDMSRGLLIFWHGKKLGPSGLKWLKIHLSNLFGFDK
LPLKDRVAFTESHLQDIKDSAENPLTGDRWWTTADKPWQALATCFELNEV
MKMDNPEEFISHQPVHQDGTCNGLQHYAALGGDVEGATQVNLVPSDKPQD
VYAHVARLVQKRLEIAAEKGDENAKILKDKITRKVVKQTVMTNVYGVTYV
GATFQIAKQLSPIFDDRKESLDFSKYLTKHVFSAIRELFHSAHLIQDWLG
ESAKRISKSIRLDVDEKSFKNGNKPDFMSSVIWTTPLGLPIVQPYREESK
KQVETNLQTVFISDPFAVNPVNARRQKAGLPPNFIHSLDASHMLLSAAEC
GKQGLDFASVHDSYWTHASDIDTMNVVLREQFIKLHEVDLVLRLKEEFDQ
RYKNYVKIGKLKRSTDLAQKIIRIRKDLSRKLGRSTTLADEIYFEKKRQE
LLNSPLIEDRNVGEKMVTTVSLFEDITDLDALEGMSVLLPLRLPEIPPKG
DFDVTVLRNSQYFFS
Ligand information
Receptor-Ligand Complex Structure
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PDB8q63 Structures illustrate step-by-step mitochondrial transcription initiation
Resolution3.68 Å
Binding residue
(original residue number in PDB)		L519 N520 R530 I536 Q594 Y638 S644 K645 R699 C801 D802 Y805 R827 Y831 P835 Y1022 T1025 V1027 Y1122 Q1129 Q1135 T1136 V1137 F1138 R1151 R1152 K1237
Binding residue
(residue number reindexed from 1)		L134 N135 R142 I148 Q171 Y215 S221 K222 R276 C374 D375 Y378 R400 Y404 P408 Y595 T598 V600 Y695 Q702 Q708 T709 V710 F711 R724 R725 K810
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0001018 mitochondrial promoter sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003896 DNA primase activity
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0000002 mitochondrial genome maintenance
GO:0006269 DNA replication, synthesis of primer
GO:0006351 DNA-templated transcription
GO:0006390 mitochondrial transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0034245 mitochondrial DNA-directed RNA polymerase complex
GO:0042645 mitochondrial nucleoid
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8q63, PDBe:8q63, PDBj:8q63
PDBsum8q63
PubMed37821701
UniProtP13433|RPOM_YEAST DNA-directed RNA polymerase, mitochondrial (Gene Name=RPO41)

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