Structure of PDB 8pnp Chain A Binding Site BS02

Receptor Information
>8pnp Chain A (length=708) Species: 1318616 (Influenza A virus (A/Zhejiang/DTID-ZJU01/2013(H7N9))) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFASICTHLEVCFMYSD
FHFIDERGESTIILKHRFEIIEGRDRTMAWTVVNSICNTTGVEKPKFLPD
LYDYKENRFIEIGVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATK
ADYTLDEESRARIKTRLFTIRQEMASRGLWDSFRQSERGEETIEERFEIT
GTMRRLADQSLPPNFSSLENFRAYVDGFEPNGCIEGKLSQMSKEVNARIE
PFLRTTPRPLRLPDGPPCSQRSKFLLMDALKLSIEDPSHEGEGIPLYDAI
KCMKTFFGWKEPNIIKPHEKGINPNYLLTWKQVLAELQDIKNEEKIPRTK
NMKKTSQLKWALGENMAPEKVDFEDCKDVNDLKQYDSDEPEPRSLACWIQ
SEFNKACELTDSSWVELDEIGEDVAPIEHIASMRRNYFTAEVSHCRATEY
IMKGVYINTALLNASCAAMDDFQLIPMISKCITKEGRRKTNLYGFIIKGR
SHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKYCVLEIGDMLLRTAVGQVS
RPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAESSVKEKDLT
KEFFENKSETWPIGESPKGVEEGSIGKVCRTLLAKSVFNSLYASPQLEGF
SAESRKLLLIVQALRDNLEPGTFDLEGLYEAIEECLINDPWVLLNASWFN
SFLTHALR
Ligand information
>8pnp Chain G (length=23) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
YSPTSPSYSPTSPSYSPTSPSYS
Receptor-Ligand Complex Structure
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PDB8pnp The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome.
Resolution2.49 Å
Binding residue
(original residue number in PDB)		A287 L288 K289 L290 L417 Y445 A448 R454 L550 R551 E613 K615 K635 R638
Binding residue
(residue number reindexed from 1)		A279 L280 K281 L282 L409 Y437 A440 R446 L542 R543 E605 K607 K627 R630
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
GO:0075523 viral translational frameshifting
GO:0075526 cap snatching
Cellular Component
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8pnp, PDBe:8pnp, PDBj:8pnp
PDBsum8pnp
PubMed38316757
UniProtM9TI86

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