Structure of PDB 8phd Chain A Binding Site BS02

Receptor Information

>8phd Chain A (length=301) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

HMKKEHVLHCQFSAWYPFFRGVTIKSVILPLPQNVKDYLLDDGTLVVSGR
DWSTATLTAPEFPEFATKVQEAINSLGGSVFPKLNWSAPRDAYWIAMNSS
LKCKTLSDIFLLFKSSDFITRDFTQPFIHCTDDSPDPCIEYELVLRKWCE
LIPGAEFRCFVKENKLIGISQRDYTQYYDHISKQKEEIRRCIQDFFKKHI
QYKFLDEDFVFDIYRDSRGKVWLIDFNPFGEVTDSLLFTWEELISENNLN
GDFSEVDAQEQDSPAFRCTNSEYLSYRLPKDFDAHKLIDFLKLKRNQQED
D

Ligand information

Ligand ID

InChI

InChI=1S/Mg/q+2

InChIKey

JLVVSXFLKOJNIY-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mg+2]
CACTVS 3.341	[Mg++]

Formula

Name

MAGNESIUM ION

PDB chain

8phd Chain A Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8phd Binding of human Cdc123 to eIF2 gamma.
Resolution	2.08 Å
Binding residue (original residue number in PDB)	D246 N248
Binding residue (residue number reindexed from 1)	D225 N227
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0000287	magnesium ion binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0044183	protein folding chaperone
GO:0046872	metal ion binding

	Biological Process
GO:0006457	protein folding
GO:1905143	eukaryotic translation initiation factor 2 complex assembly

	Cellular Component
GO:0005737	cytoplasm

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Molecular Function

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Cellular Component

External links

PDB	RCSB:8phd, PDBe:8phd, PDBj:8phd
PDBsum	8phd
PubMed	37507029
UniProt	O75794\|CD123_HUMAN Translation initiation factor eIF2 assembly protein (Gene Name=CDC123)

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