Structure of PDB 8pfh Chain A Binding Site BS02

Receptor Information
>8pfh Chain A (length=272) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FQFNIMVVGQSGLGKSTLINTLFASHLIDSATGDDISALPVTKTTEMKIS
THTLVEDRVRLNINVIDTPGFGDFIDNSKAWEPIVKYIKEQHSQYLRKEL
TAQRERFITDTRVHAILYFLQPNGKELSRLDVEALKRLTEIANVIPVIGK
SDTLTLDERTEFRELIQNEFEKYNFKIYPYDSEELTDEELELNRSVRSII
PFAVVGSENEIEINRGRKTRWSAINVEDINQCDFVYLREFLIRTHLQDLI
ETTSYIHYEGFRARQLIALKEN
Ligand information
Ligand IDGDP
InChIInChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1
InChIKeyQGWNDRXFNXRZMB-UUOKFMHZSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.6c1nc2c(n1C3C(C(C(O3)COP(=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
CACTVS 3.385NC1=Nc2n(cnc2C(=O)N1)[C@@H]3O[C@H](CO[P](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
CACTVS 3.385NC1=Nc2n(cnc2C(=O)N1)[CH]3O[CH](CO[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 12.01O=P(O)(O)OP(=O)(O)OCC3OC(n2cnc1c2N=C(N)NC1=O)C(O)C3O
OpenEye OEToolkits 1.7.6c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
FormulaC10 H15 N5 O11 P2
NameGUANOSINE-5'-DIPHOSPHATE
ChEMBLCHEMBL384759
DrugBankDB04315
ZINCZINC000008215481
PDB chain8pfh Chain B Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8pfh Crystal structure of the yeast septin complex Shs1-Cdc12-Cdc3-Cdc10
Resolution3.24 Å
Binding residue
(original residue number in PDB)		T183 E188
Binding residue
(residue number reindexed from 1)		T153 E158
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0005545 1-phosphatidylinositol binding
GO:0010314 phosphatidylinositol-5-phosphate binding
GO:0060090 molecular adaptor activity
GO:0070273 phosphatidylinositol-4-phosphate binding
Biological Process
GO:0000281 mitotic cytokinesis
GO:0000920 septum digestion after cytokinesis
GO:0000921 septin ring assembly
GO:0008104 protein localization
GO:0010458 exit from mitosis
GO:0032186 cellular bud neck septin ring organization
GO:0043934 sporulation
GO:0051301 cell division
GO:0061640 cytoskeleton-dependent cytokinesis
Cellular Component
GO:0000144 cellular bud neck septin ring
GO:0001400 mating projection base
GO:0005619 ascospore wall
GO:0005628 prospore membrane
GO:0005876 spindle microtubule
GO:0005935 cellular bud neck
GO:0005940 septin ring
GO:0015630 microtubule cytoskeleton
GO:0016020 membrane
GO:0031105 septin complex
GO:0032153 cell division site
GO:0032160 septin filament array
GO:0042764 ascospore-type prospore
GO:0043332 mating projection tip
GO:0072687 meiotic spindle
GO:1990317 Gin4 complex

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Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8pfh, PDBe:8pfh, PDBj:8pfh
PDBsum8pfh
PubMed38184752
UniProtP25342|CDC10_YEAST Cell division control protein 10 (Gene Name=CDC10)

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