Structure of PDB 8pd6 Chain A Binding Site BS02

Receptor Information
>8pd6 Chain A (length=181) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SIPGRRELLRKFQVDVKLDPATAHPSLLLTADLRSVQDGEDVPNNPERFD
TWPCILGLQSFSSGRHYWEVLVGEGAEWGLGVCQDTLPRKGETTPSPENG
VWALWLLKGNEYMVLASPSVPLLQLESPRCIGIFLDYEAGEISFYNVTDG
SYIYTFNQLFSGLLRPYFFICDATPLILPPT
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain8pd6 Chain A Residue 503 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8pd6 Discovery of Ligands for TRIM58, a Novel Tissue-Selective E3 Ligase.
Resolution1.3 Å
Binding residue
(original residue number in PDB)		Q364 T366 L443
Binding residue
(residue number reindexed from 1)		Q84 T86 L163
Annotation score4
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
External links
PDB RCSB:8pd6, PDBe:8pd6, PDBj:8pd6
PDBsum8pd6
PubMed38116426
UniProtQ8NG06|TRI58_HUMAN E3 ubiquitin-protein ligase TRIM58 (Gene Name=TRIM58)

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