Structure of PDB 8p0k Chain A Binding Site BS02

Receptor Information
>8p0k Chain A (length=1277) Species: 10245 (Vaccinia virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AVISKVTYSLYDQKEINATDIIISHVKNDDDIGTVKDGRLGAMDGALCKT
CGKTELECFGHWGKVSIYKTHIVKPEFISEIIRLLNHICIHCGLLRSREP
YSDDINLKELSGHALRRLKDKILSKKKSCWNSECMQPYQKITFSKKKVCF
VNKLDDINVPNSLIYQKLISIHEKFWPLLEIHQYPANLFYTDYFPIPPLI
IRPAISETNELTYLLGMIVKNCNLNADEQVIQKAVIEYDDIKIISNNTTS
INLSYITSGKNNMIRSYIVARRKDQTARSVIGPSTSITVNEVGMPAYIRN
TLTEKIFVNAFTVDKVKQLLASNQVKFYFNKRLNQLTRIRQGKFIKNKIH
LLPGDWVEVAVQEYTSIIFGRQPSLHRYNVIASSIRATEGDTIKISPGIA
NSQNADFDGDEEWMILEQNPKAVIEQSILMYPTTLLKHDIHGAPVYGSIQ
DEIVAAYSLFRIQDLCLDEVLNILGKYGREFDPKGKCKFSGKDIYTYLIG
EKINYPGLLKDGEIIANDVDSNFVVAMRHLSLAGLLSDHKSNVEGINFII
KSSYVFKRYLSIYGFGVTFKDLRPNSTFTNKLEAINVEKIELIKEAYAKY
LNDVRDGKIVPLSKALEADYVESMLSNLTNLNIREIEEHMRQTLIDDPDN
NLLKMAKAGYKVNPTELMYILGTYGQQRIDGEPAETRVLGRVLPYYLPDS
KDPEGRGYILNSLTKGLTGSQYYFSMLVARSQSTDIVCETSRTGTLARKI
IKKMEDMVVDGYGQVVIGNTLIKYAANYTKILGSVCKPVDLIYPDESMTW
YLEISALWNKIKQGFVYSQKQKLAKKTLAPFNFLVFVKPTTEDNAIKVKD
LYDMIHNVIDDVREKYFFTVSNIDFMEYIFLTHLNPSRIRITKETAITIF
EKFYEKLNYTLGGGTPIGIISAQVLSEKFTQQALSSFHTTEKSGAVKQKL
GFNEFNNLTNLSKNKTEIITLVSDDISKLQSVKINFEFVCLGELNPNITL
RKETDKYVVDIIVNRLYIKRAEITELVVEYMIERFISFSVIVKEWGMETF
IEDEDNIRFTVYLNFVEPEELNLSKFMMVLPGAANKGKISKFKIPISDYT
GYDDFNQTKKLNKMTVELMNLKELGSFDLENVNVYPGVWNTYDIFGIEAA
REYLCEAMLNTYGEGFDYLYQPCDLLASLLCASYEPESVNKFKFGAASTL
KRATFGDNKALLNAALHKKSEPINDNSSCHFFSKVPNIGTGYYKYFIDLG
LLMRMERKLSDKISSQKIKEMEETEDF
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8p0k Cryo EM map and model of the vaccinia RNA polymerase intermediate pre-initiation open promoter complex (CASP target)
Resolution2.64 Å
Binding residue
(original residue number in PDB)		K269 T749 S750 G753 T754
Binding residue
(residue number reindexed from 1)		K260 T740 S741 G744 T745
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0044423 virion component

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:8p0k, PDBe:8p0k, PDBj:8p0k
PDBsum8p0k
PubMed
UniProtP20504|RP147_VACCC DNA-directed RNA polymerase 147 kDa polypeptide (Gene Name=OPG105)

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