Structure of PDB 8opt Chain A Binding Site BS02

Receptor Information
>8opt Chain A (length=783) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PVIDESVLSTKELLGLQQAEERLKRDCIDRLKRRPRNYPTAKYTCRLCDV
LIESIAFAHKHIKEKRHKKNIKEKQEEELLTTLPPPTPSQINAVGIAIDK
VVQEFGLHNENLEQRLEIKRIMENVFQHKLPDCSLRLYGSSCSRLGFKNS
DVNIDIQFPAIMSQPDVLLLVQECLKNSDSFIDVDADFHARVPVVVCREK
QSGLLCKVSAGNENACLTTKHLTALGKLEPKLVPLVIAFRYWAKLCSIDR
PEEGGLPPYVFALMAIFFLQQRKEPLLPVYLGSWIEGFSLSKLGNFNLQD
IEKDVVIWEHTDSPIKRGQVSLILDVKHQPSVPVGQLWVELLRFYALEFN
LADLVISIRVKELVSRELKDWPKKRIAIEDPYSVKRNVARTLNSQPVFEY
ILHCLRTTYKYFADFFYEFSKLIFTKGKSPTVVCSLCKREGHLKKDCPED
FKRILEPLPPLTPKFLNILDQVCIQCYKDFSPTIIEDQAREHIRQNLESF
IRQDFPGTKLSLFGSSKNGFGFKQSDLDVCMTINGLGLDCVRTIEELARV
LRKHSGLRNILPITTAKVPIVKFFHLRSGLEVDISLYNTLALHNTRLLSA
YSAIDPRVKYLCYTMKVFTKMCDIGDASRGSLSSYAYTLMVLYFLQQRNP
PVIPVLQEIPEIFVDGWNIYFFDQIDELPTYWSECGKNTESVGQLWLGLL
RFYTEEFDFKEHVISIRRKSLLTTFKKQWTIVIEDPFDLNHNLGAGLSRK
MTNFIMKAFINGRRVFGIPVYPSKMEYFFDPDV
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8opt Chain A Residue 1501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8opt Structural basis for activity switching in polymerases determining the fate of let-7 pre-miRNAs
Resolution3.65 Å
Binding residue
(original residue number in PDB)		C965 C968 H973
Binding residue
(residue number reindexed from 1)		C434 C437 H442
Annotation score1
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0016779 nucleotidyltransferase activity
GO:0035198 miRNA binding
GO:0046872 metal ion binding
GO:0050265 RNA uridylyltransferase activity
GO:0070569 uridylyltransferase activity
Biological Process
GO:0001556 oocyte maturation
GO:0010586 miRNA metabolic process
GO:0031054 pre-miRNA processing
GO:0031123 RNA 3'-end processing
GO:0071044 histone mRNA catabolic process
GO:0071076 RNA 3' uridylation
GO:0141008 retrotransposon silencing by mRNA destabilization
GO:1990074 polyuridylation-dependent mRNA catabolic process
Cellular Component
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol

View graph for
Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8opt, PDBe:8opt, PDBj:8opt
PDBsum8opt
PubMed39054354
UniProtQ5VYS8|TUT7_HUMAN Terminal uridylyltransferase 7 (Gene Name=TUT7)

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