Structure of PDB 8op1 Chain A Binding Site BS02

Receptor Information

>8op1 Chain A (length=378) Species: 12814 (Respiratory syncytial virus)

ALSKVKLNDTLNKDQLLSSSKYTIQRSTGDSIDTPNYDVQKHINKLCGML
LITEDANHKFTGLIGMLYAMSRLGREDTIKILRDAGYHVKANGVDVTTHR
QDINGKEMKFEVLTLASLTTEIQINIEIESRKSYKKMLKEMGEVAPEYRH
DSPDCGMIILCIAALVITKLAAGDRSGLTAVIRRANNVLKNEMKRYKGLL
PKDIANSFYEVFEKHPHFIDVFVHFGIAQSSTRGGSRVEGIFAGLFMNAY
GAGQVMLRWGVLAKSVKNIMLGHASVQAEMEQVVEVYEYAQKLGGEAGFY
HILNNPKASLLSLTQFPHFSSVVLGNAAGLGIMGEYRGTPRNQDLYDAAK
AYAEQLKENGVINYSVLDLTAEELEAIK

Ligand information

>8op1 Chain G (length=7)

ccccccc

.......

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8op1 Structural landscape of the respiratory syncytial virus nucleocapsids.
• Resolution: 3.5 Å
• Binding residue (original residue number in PDB): R185 N188 V189 I242
• Binding residue (residue number reindexed from 1): R184 N187 V188 I241

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0005515 protein binding
• GO:0030291 protein serine/threonine kinase inhibitor activity

Biological Process

• GO:0019049 virus-mediated perturbation of host defense response
• GO:0039502 symbiont-mediated suppression of host type I interferon-mediated signaling pathway
• GO:0039545 symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity
• GO:0039554 symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MDA-5 activity
• GO:0039580 symbiont-mediated suppression of host PKR/eIFalpha signaling
• GO:0085034 symbiont-mediated suppression of host NF-kappaB cascade

Cellular Component

• GO:0019013 viral nucleocapsid
• GO:0019028 viral capsid
• GO:0019029 helical viral capsid
• GO:0030430 host cell cytoplasm
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8op1, PDBe:8op1, PDBj:8op1
• PDBsum: 8op1
• PubMed: 37714861
• UniProt: P03418|NCAP_HRSVA Nucleoprotein (Gene Name=N)