Structure of PDB 8oo6 Chain A Binding Site BS02

Receptor Information
>8oo6 Chain A (length=604) Species: 866768 (Escherichia coli 'BL21-Gold(DE3)pLysS AG') [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GPHDNYVTILDEETLKAWIAKLEKAPVFAFDTETDSLDNISANLVGLSFA
IEPGVAAYIPVAHDYLDAPDQISRERALELLKPLLEDEKALKVGQNLKYD
RGILANYGIELRGIAFDTMLESYILNSVAGRHDMDSLAERWLKHKTITFE
EIAGKGKNQLTFNQIALEEAGRYAAEDADVTLQLHLKMWPDLQKHKGPLN
VFENIEMPLVPVLSRIERNGVKIDPKVLHNHSEELTLRLAELEKKAHEIA
GEEFNLSSTKQLQTILFEKQGIKPLKKTPGGAPSTSEEVLEELALDYPLP
KVILEYRGLAKLKSTYTDKLPLMINPKTGRVHTSYHQAVTATGRLSSTDP
NLQNIPVRNEEGRRIRQAFIAPEDYVIVSADYSQIELRIMAHLSRDKGLL
TAFAEGKDIHRATAAEVFGLPLETVTSEQRRSAKAINFGLIYGMSAFGLA
RQLNIPRKEAQKYMDLYFERYPGVLEYMERTRAQAKEQGYVETLDGRRLY
LPDIKSSNGARRAAAERAAINAPMQGTAADIIKRAMIAVDAWLQAEQPRV
RMIMQVHDELVFEVHKDDVDAVAKQIHQLMENCTRLDVPLLVEVGSGENW
DQAH
Ligand information
Receptor-Ligand Complex Structure
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PDB8oo6 A four-point molecular handover during Okazaki maturation.
Resolution4.3 Å
Binding residue
(original residue number in PDB)		T602 S608 T609 E611 R631 Y640 N678 P680 R682 E710 K758 A759 F762 H881 D882
Binding residue
(residue number reindexed from 1)		T278 S284 T285 E287 R307 Y316 N354 P356 R358 E386 K434 A435 F438 H557 D558
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0008408 3'-5' exonuclease activity
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication

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Molecular Function
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Biological Process
External links
PDB RCSB:8oo6, PDBe:8oo6, PDBj:8oo6
PDBsum8oo6
PubMed37620586
UniProtP00582|DPO1_ECOLI DNA polymerase I (Gene Name=polA)

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