Structure of PDB 8okd Chain A Binding Site BS02

Receptor Information
>8okd Chain A (length=291) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KRAFDFSAHGRRHVALRIAYMGWGYQGFASQENTNNTIEEKLFEALTKTR
LVESRQTSNYHRCGRTAKGVSAFGQVISLDLRSQFPEEIRYTHILNRVLP
PDIRILAWAPVEPSFSARFSCLERTYRYFFPRADLDIVTMDYAAQKYVGT
HDFRNLCKMDVANGVINFQRTILSAQVQLVQEPFQLCQFEVTGQAFLYHQ
VRCMMAILFLIGQGMEKPEIIDELLNIEKNPQKPQYSMAVEFPLVLYDCK
FENVKWIYDQEAQEFNITHLQQLWANHAVKTHMLYSMLQGL
Ligand information
>8okd Chain X (length=70) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggccccaugguguaaugguuagcacucuggacauccagcgauccgaguuc
aaaucucggugggaccucca
<<.<<<<..<<<<........>>>>.<<<<<..>>>>>....<<<<<...
....>>>>>>>>>.>>....
Receptor-Ligand Complex Structure
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PDB8okd The molecular basis of tRNA selectivity by human pseudouridine synthase 3.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		Q82 N84 R116 K119 K227 R239 Y276 S315
Binding residue
(residue number reindexed from 1)		Q31 N33 R65 K68 K158 R170 Y198 S237
Gene Ontology
Molecular Function
GO:0009982 pseudouridine synthase activity
GO:0016853 isomerase activity
GO:0160154 tRNA pseudouridine(38/39) synthase activity
Biological Process
GO:0006400 tRNA modification
GO:0008033 tRNA processing
GO:0031119 tRNA pseudouridine synthesis
GO:1990481 mRNA pseudouridine synthesis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8okd, PDBe:8okd, PDBj:8okd
PDBsum8okd
PubMed38996458
UniProtQ9BZE2|PUS3_HUMAN tRNA pseudouridine(38/39) synthase (Gene Name=PUS3)

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