Structure of PDB 8ofl Chain A Binding Site BS02

Receptor Information
>8ofl Chain A (length=306) Species: 1639 (Listeria monocytogenes) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KVGLLVMAYGTPYKDEDIERYYTDIRHGHKPSEEMIADLRGRYHAIGGLS
PLAKITEAQAYGLEKALNDSQDEVEFKAYIGLKHIEPFIEDAVEAMHKDG
IEEAISIVLAPHYSSFSVEAYNKRAKEAADKLGGPRINAINDWYKQPKFI
QMWADRINETAKQIPADELLDTVLIVSAHSLPEKIKQHNDPYPNQLQETA
DFIFEKVVVPHYALGWQSEGKTGEPWLGPDVQDLTRELYGREKYKHFIYT
PVGFVAEHLEVLYDNDYECKVVTDEVGAAYHRPPMPNSDPEFLEVLRTVV
WEKYSN
Ligand information
Ligand IDFE2
InChIInChI=1S/Fe/q+2
InChIKeyCWYNVVGOOAEACU-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Fe+2]
CACTVS 3.341[Fe++]
FormulaFe
NameFE (II) ION
ChEMBL
DrugBankDB14510
ZINC
PDB chain8ofl Chain A Residue 405 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8ofl Coproporphyrin III - LmCpfC soaked 4min with Fe2+
Resolution2.1 Å
Binding residue
(original residue number in PDB)		Y12 H182
Binding residue
(residue number reindexed from 1)		Y9 H179
Annotation score5
Enzymatic activity
Enzyme Commision number 4.99.1.9: coproporphyrin ferrochelatase.
Gene Ontology
Molecular Function
GO:0004325 ferrochelatase activity
GO:0016829 lyase activity
GO:0046872 metal ion binding
Biological Process
GO:0006783 heme biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ofl, PDBe:8ofl, PDBj:8ofl
PDBsum8ofl
PubMed37743577
UniProtQ8Y565|CPFC_LISMO Coproporphyrin III ferrochelatase (Gene Name=cpfC)

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