Structure of PDB 8kho Chain A Binding Site BS02

Receptor Information
>8kho Chain A (length=287) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SHSIVLPAAVSSAHPVPKHIKKPDYVTTGIVPDWGDSIEVKNEDQIQGLH
QACQLARHVLLLAGKSLKVDMTTEEIDALVHREIISHNAYPSPLGYGGFP
KSVCTSVNNVLCHGIPDSRPLQDGDIINIDVTVYYNGYHGDTSETFLVGN
VDECGKKLVEVARRCRDEAIAACRAGAPFSVIGNTISHITHQNGFQVCPH
FVGHGIGSYFHGHPEIWHHANDSDLPMEEGMAFTIEPIITEGSPEFKVLE
DAWTVVSLDNQRSAQFEHTVLITSRGAQILTKLPHEA
Ligand information
Ligand IDCO
InChIInChI=1S/Co/q+2
InChIKeyXLJKHNWPARRRJB-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Co+2]
CACTVS 3.341[Co++]
FormulaCo
NameCOBALT (II) ION
ChEMBL
DrugBankDB14205
ZINC
PDB chain8kho Chain A Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8kho Structural insights into N-terminal methionine cleavage by the human mitochondrial methionine aminopeptidase, MetAP1D.
Resolution1.45 Å
Binding residue
(original residue number in PDB)		D189 H252 T282 E284 E315
Binding residue
(residue number reindexed from 1)		D141 H204 T234 E236 E267
Annotation score3
Enzymatic activity
Enzyme Commision number 3.4.11.18: methionyl aminopeptidase.
Gene Ontology
Molecular Function
GO:0070006 metalloaminopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:8kho, PDBe:8kho, PDBj:8kho
PDBsum8kho
PubMed38102161
UniProtQ6UB28|MAP12_HUMAN Methionine aminopeptidase 1D, mitochondrial (Gene Name=METAP1D)

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