Structure of PDB 8kgm Chain A Binding Site BS02

Receptor Information
>8kgm Chain A (length=1181) Species: 10497 (African swine fever virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AFEISDFKEHAKKKSMWAGALNKVTISGLMGVFTEDEDLMALPIHRDHCP
ALLKIFDEIIVNATDHERACHNKTKKVTYIKISFDKGVFSCENDGPGIPI
AKHEQASLIAKRDVYVPEVASCHFLAGTNINKAKDCIKGGTNGVGLKLAM
VHSQWAILTTADGAQKYVQHINQRLDIIEPPTITPSREMFTRIELMPVYQ
ELGYAEPLSETEQADLSAWIYLRACQCAAYVGKGTTIYYNDKPCRTGSVM
ALAKMYTLLSAPNSTIHTATIKADAKPYSLHPLQVAAVVSPKFKKFEHVS
VINGVNCVKGEHVTFLKKTINEMVVKKFQQTIKDKNRKTTLRDSCSNIFI
VIVGSIPGIEWTGQRKDELSIAENVFKTHYSIPSSFLTSMTKSIVDILLQ
SVDVDKYTRARNAGGKRAQDCMLLAAEGDSALSLLRTGLTLGKSNPSGPS
FDFCGMISLGGVIMNACKKVTNITTDSGETIMVRNEQLTNNKVLQGIVQV
LGLDFNCHYKTQEERAKLRYGCIVACVDQDLDGCGKILGLLLAYFHLFWP
QLIIHGFVKRLLTPLIRVYEKGKTMPVEFYYEQEFDAWAKKQTSLANHTV
KYYKGLAAHDTHEVKSMFKHFDNMVYTFTLDDSAKELFHIYFGGESELRK
RELCTGVVPLTETQTQSIHSVRRIPCSLHLQVDTKAYKLDAIERQIPNFL
DGMTRARRKILAGGVKCFASNNRERKVFQFGGYVADHMFYHHGDMSLNTS
IIKAAQYYPGSSHLYPVFIGIGSFGSRHLGGKDAGSPRYISVQLASEFIK
TMFPAEDSWLLPYVFEDGQRAEPEYYVPVLPLAIMEYGANPSEGWKYTTW
ARQLEDILALVRAYVDKDNPKHELLHYAIKHKITILPLRPSNYNFKGHLK
RFGQYYYSYGTYVISEQRNIITITELPLRVPTVAYIESIKKSSNRMTFIE
EIIDYSSSETIEILVKLKPNSLNRIVEEFKETEEQDSIENFLRLRNCLHS
HLNFVKPKGGIIEFNTYYEILYAWLPYRRELYQKRLMREHAVLKLRIIME
TAIVRYINESAELNLSHYEDEKEASRILSEHGFPPLNHTLIISPEFASIE
ELNQKALQGCYTYILSLQARELLIAAKTRRVEKIKKMQARLDKVEQLLQE
SPFPGASVWLEEIDAVEKAIIKGRNTQWKFH
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8kgm Structure of African swine fever virus topoisomerase II in complex with dsDNA
Resolution4.8 Å
Binding residue
(original residue number in PDB)		G472 V473 N496 D543 R705 Q706 T715 R718 H753 A850 N851 P852
Binding residue
(residue number reindexed from 1)		G461 V462 N485 D532 R694 Q695 T704 R707 H742 A839 N840 P841
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
GO:0016853 isomerase activity
GO:0046872 metal ion binding
Biological Process
GO:0000819 sister chromatid segregation
GO:0006259 DNA metabolic process
GO:0006265 DNA topological change
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8kgm, PDBe:8kgm, PDBj:8kgm
PDBsum8kgm
PubMed38816407
UniProtA0A2X0THW2

[Back to BioLiP]