Structure of PDB 8k7c Chain A Binding Site BS02

Receptor Information
>8k7c Chain A (length=587) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RDFGRKLRLLSGYLWPRGSPALQLVVLICLGLMGLERALNVLVPIFYRNI
VNLLTEKAPWNSLAWTVTSYVFLKFLQGGGTGSTGFVSNLRTFLWIRVQQ
FTSRRVELLIFSHLHELSLRWHLGRRTGEVLRIADRGTSSVTGLLSYLVF
NVIPTLADIIIGIIYFSMFFNAWFGLIVFLCMSLYLTLTIVVTEWRTKFR
RAMNTQENATRARAVDSLLNFETVKYYNAESYEVERYREAIIKYQGLEWK
SSASLVLLNQTQNLVIGLGLLAGSLLCAYFVTEQKLQVGDYVLFGTYIIQ
LYMPLNAFGTYYRMIQTNFIDMENMFDLLKEETEVKDLPGAGPLRFQKGR
IEFENVHFSYADGRETLQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRF
YDISSGCIRIDGQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIRYGRV
TAGNDEVEAAAQAAGIHDAIMAFPEGYRTQVGERGLKLSGGEKQRVAIAR
TILKAPGIILLDEATSALDTSNERAIQASLAKVCANRTTIVVAHRLSTVV
NADQILVIKDGCIVERGRHEALLSRGGVYADMWQLQQ
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain8k7c Chain A Residue 903 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8k7c W546 stacking disruption traps the human porphyrin transporter ABCB6 in an outward-facing transient state.
Resolution3.9 Å
Binding residue
(original residue number in PDB)		S630 Q671
Binding residue
(residue number reindexed from 1)		S391 Q432
Annotation score1
Enzymatic activity
Enzyme Commision number 7.6.2.5: ABC-type heme transporter.
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0140359 ABC-type transporter activity
Biological Process
GO:0055085 transmembrane transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8k7c, PDBe:8k7c, PDBj:8k7c
PDBsum8k7c
PubMed37735522
UniProtQ9NP58|ABCB6_HUMAN ATP-binding cassette sub-family B member 6 (Gene Name=ABCB6)

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