Structure of PDB 8k4l Chain A Binding Site BS02

Receptor Information

>8k4l Chain A (length=216) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

NSTAADEVTAHLAAAGPVGMAAAAAVATGKKRKRPHVFESNPSIRKRQQT
RLLRKLRATLDEYTTRVGQQAIVLCISPSKPNPVFKVFGAAPLENVVRKY
KSMILEDLESALAENSELPPLTIDGIPVSVDKMTQAQLRAFIPEMLKYST
GRGKPGWGKESCKPIWWPEDIPWANVRSDVRTEEQKQRVSWTQALRTIVK
NCYKQHGREDLLYAFE

Ligand information

>8k4l Chain D (length=14) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

atgcgcatgcgcat

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8k4l Crystal structure of NRF1 homodimer in complex with DNA
Resolution	2.1 Å
Binding residue (original residue number in PDB)	T109 T201 Q202 A203 R206 R244 S245 D246
Binding residue (residue number reindexed from 1)	T50 T134 Q135 A136 R139 R177 S178 D179

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003700	DNA-binding transcription factor activity

	Biological Process
GO:0006357	regulation of transcription by RNA polymerase II

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Molecular Function

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Biological Process

External links

PDB	RCSB:8k4l, PDBe:8k4l, PDBj:8k4l
PDBsum	8k4l
PubMed	38055835
UniProt	Q16656\|NRF1_HUMAN Nuclear respiratory factor 1 (Gene Name=NRF1)

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