Structure of PDB 8k0m Chain A Binding Site BS02

Receptor Information

>8k0m Chain A (length=643) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GMVTPDLLFAEGTAAYARGDWPGVVLSMERALRSRAALRALRLRCRTQCA
ADFPWELDPDWSPSPAQASGAAALRDLSFFGGLLRRAACLRRCLGPPAAH
SLSEEMELEFRKRSPYNYLQVAYFKINKLEKAVAAAHTFFVGNPEHMEMQ
QNLDYYQTMSGVKEADFKDLETQPHMQEFRLGVRLYSEEQPQEAVPHLEA
ALQEYFVAYEECRALCEGPYDYDGYNYLEYNADLFQAITDHYIQVLNCKQ
NCVTELASHPSREKPFEDFLPSHYNYLQFAYYNIGNYTQAVECAKTYLLF
FPNDEVMNQNLAYYAAMLGEEHTRSIGPRESAKEYRQRSLLEKELLFFAY
DVFGIPFVDPDSWTPEEVIPKRLQEKQKSERETAVRISQEIGNLMKEIDV
SRLTREGGPLLYEGISLTMNSKLLNGSQRVVMDGVISDHECQELQRLTNV
AATEKFYGVTVFKALKLGQEGKVPLQSAHLYYNVTEKVRRIMESYFRLDT
PLYFSYSHLVCRTAIEEVQAERKDDSHPVHVDNCILNAETLVCVKEPPAY
TFRDYSAILYLNGDFDGGNFYFTELDAKTVTAEVQPQCGRAVGFSSGTEN
PHGVKAVTRGQRCAIALWFTLDPRHSERDRVQADDLVKMLFSP

Ligand information

Ligand ID

AKG

InChI

InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)

InChIKey

KPGXRSRHYNQIFN-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04	O=C(O)C(=O)CCC(=O)O
OpenEye OEToolkits 1.7.6	C(CC(=O)O)C(=O)C(=O)O
CACTVS 3.385	OC(=O)CCC(=O)C(O)=O

Formula

C5 H6 O5

Name

2-OXOGLUTARIC ACID

PDB chain

8k0m Chain A Residue 804 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8k0m The structural basis for the collagen processing by human P3H1/CRTAP/PPIB ternary complex.
Resolution	3.17 Å
Binding residue (original residue number in PDB)	H587 F627 H659 V661 W675
Binding residue (residue number reindexed from 1)	H530 F570 H602 V604 W618
Annotation score	5

External links

PDB	RCSB:8k0m, PDBe:8k0m, PDBj:8k0m
PDBsum	8k0m
PubMed	39245686
UniProt	Q32P28\|P3H1_HUMAN Prolyl 3-hydroxylase 1 (Gene Name=P3H1)

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