Structure of PDB 8jxd Chain A Binding Site BS02

Receptor Information
>8jxd Chain A (length=493) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RKPTHKPCTDTEYKCSNGNCISQHYVCDNVNDCGDLSDETGCNLGDNRTC
AENICEQNCTQLSSGGFICSCRPGFKPSTLDKNSCQDINECEEFGICPQS
CRNSKGSYECFCVDGFKSMSTHYGERCAADGSPPLLLLPENVRIRKYNTS
SEKFSEYLEEEEHIQTIDYDWDPEHIGLSVVYYTVLAQGSQFGAIKRAYI
PNFESGSNNPIREVDLGLKYLMQPDGLAVDWVGRHIYWSDAKSQRIEVAT
LDGRYRKWLITTQLDQPAAIAVNPKLGLMFWTDQGKQPKIESAWMNGEHR
SVLVSENLGWPNGLSIDYLNDDRVYWSDSKEDVIEAIKYDGTDRRLIINE
AMKPFSLDIFEDKLYWVAKEKGEVWRQNKFGKENKEKVLVVNPWLTQVRI
FHQLRYNQSVSNPCKQVCSHLCLLRPGGYSCACPQGSDFVTGSTVQCDAA
SELPVTMPPPCRCMHGGNCYFDENELPKCKCSSGYSGEYCEVG
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain8jxd Chain A Residue 4703 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8jxd Cryo-EM structures elucidate the multiligand receptor nature of megalin.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		D4009 I4010 E4012 N4025 S4026 G4028 S4029
Binding residue
(residue number reindexed from 1)		D87 I88 E90 N103 S104 G106 S107
Annotation score4
External links
PDB RCSB:8jxd, PDBe:8jxd, PDBj:8jxd
PDBsum8jxd
PubMed38771880
UniProtP98158|LRP2_RAT Low-density lipoprotein receptor-related protein 2 (Gene Name=Lrp2)

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