Structure of PDB 8jx8 Chain A Binding Site BS02

Receptor Information

>8jx8 Chain A (length=1436) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

CPTQPFHCPSTQWQCPGYSTCINLSALCDGVFDCPNGTDESPLCNQDSCS
HFNGGCTHQCMQGPFGATCLCPLGYQLANDTKTCEDINECDIPGFCSQHC
VNMRGSFRCACDPEYTLESDGRTCKVTGSENPLLVVASRDKIIVDNITAH
THNLYSLVQDVSFVVALDFDSVTGRVFWSDLLQGKTWSVFQNGTDKRVVH
DSGLSVTEMIAVDWIGRNLYWTDYALETIEVSKIDGSHRTVLISKNVTKP
RGLALDPRMGDNVMFWSDWGHHPRIERASMDGTMRTVIVQEKIYWPCGLS
IDYPNRLIYFMDAYLDYIEFCDYDGHNRRQVIASDLVLHHPHALTLFEDF
VYWTDRGTRQVMQANKWHGGNQSVVMYSVHQPLGITAIHPSRQPPSRNPC
ASASCSHLCLLSAQAPRHYSCACPSGWNLSDDSVNCVRGDQPFLMSVRDN
IIFGISLDPEVKSNDAMVPISGIQHGYDVEFDDSEQFIYWVENPGEIHRV
KTDGSNRTVFAPLSLLGSSLGLALDWVSRNIYYTTPASRSIEVLTLKGDT
RYGKTLIANDGTPLGVGFPVGIAVDPARGKLYWSDHGTDSGVPAKIASAN
MDGTSLKILFTGNLQHLEVVTLDIQEQKLYWAVTSRGVIERGNVDGTERM
ILVHHLAHPWGLVVYGSFLYYSDEQYEVIERVDKSSGNNKVVLRDNVPYL
RGLRVYHRRNAADSSNGCSNNPNACQQICLPVPGGMFSCACASGFKLSPD
GRSCSPYNSFMVVSMLPAVRGFSLELSDHSEAMVPVAGQGRNVLHADVDV
ANGFIYWCDFSSSVRSSNGIRRIKPDGSNFTNVVTYGIGANGIRGVALDW
AAGNLYFTNAFVYETLIEVLRINTTYRRVLLKVSVDMPRHIIVDPKHRYL
FWADYGQKPKIERSFLDCTNRTVLVSEGIVTPRGLAMDHDTGYIYWVDDS
LDLIARIHLDGGESQVVRYGSRYPTPYGITVFGESIIWVDRNLKKVFQAS
KQPGNTDPPVVIRDKINLLRDVTIFDEHAQPLSPAELNNNPCLQSNGGCS
HFCFALPELPTPRCGCAFGTLGNDGKSCATSQEDFLIYSLNNSLRSLHFD
PRDHSLPFQVISVAGTAIALDYDRRNNRIFFTQKLNSLRGQISYVSLYSG
SSSPTVLLSNIGVTDGIAFDWINRRIYYSDFSNQTINSMAEDGSNRAVIA
RVSKPRAIVLDPCRGYMYWTDWGTNAKIERATLGGNFRVPIVNTSLVWPN
GLALDLETDLLYWADASLQKIERSTLTGTNREVVVSTAFHSFGLTVYGQY
IYWTDLYTRKIYRANKYDGSDLVAMTTRLPTQPSGISTVVKTQRQQCSNP
CDQFNGGCSHICAPGPNGAECQCPHEGNWYLANDNKYCVVDTGTRCNQLQ
FTCLNGHCINQDWKCDNDNDCGDGSDELPTVCAFHT

Ligand information

>8jx8 Chain K (length=5) Species: 10116 (Rattus norvegicus) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

AEEAA

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8jx8 Cryo-EM structures elucidate the multiligand receptor nature of megalin.
Resolution	3.3 Å
Binding residue (original residue number in PDB)	F2115 R2149 R2194 R2296 R2325
Binding residue (residue number reindexed from 1)	F810 R844 R889 R991 R1020

External links

PDB	RCSB:8jx8, PDBe:8jx8, PDBj:8jx8
PDBsum	8jx8
PubMed	38771880
UniProt	P98158\|LRP2_RAT Low-density lipoprotein receptor-related protein 2 (Gene Name=Lrp2)

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