Structure of PDB 8jtj Chain A Binding Site BS02

Receptor Information
>8jtj Chain A (length=1042) Species: 1422 (Geobacillus stearothermophilus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MRYKIGLDIGITSVGWAVMNLDIPRIEDLGVRIFDRAENPQTGESLALPR
RLARSARRRLRRRKHRLERIRRLVIREGILTKEELDKLFEEKHEIDVWQL
RVEALDRKLNNDELARVLLHLAKRRGFKSNRKSKENSTMLKHIEENRAIL
SSYRTVGEMIVKDPKFALHKRNKGENYTNTIARDDLEREIRLIFSKQREF
GNMSCTEEFENEYIAIWASQRPVASKDDIEKKVGFCAFEPKEKRAPKATY
TFQSFIAWEHINKLRLISPSGARGLTDEERRLLYEQAFQKNKITYHDIRT
LLHDTYFKGIVYDRQNENIRFLELDAYHQIRKAVDKVYGKEKSSSFLPID
FDTFGYALTLFKDDADIHSYLRNEYEQNGKRMPNLANKVYDNELIEELLN
LSFTKFGHLSLKALRSILPYMEQGEVYSSACERAGYTFTGPKKKQKTMLL
PNIPPIANPVVMRALTQARKVVNAIIKKYGSPVSIHIELARDLSQTFDER
RKTKKEQDENRKKNETAIRQLMEYGLTLNPTGHDIVKFKLWSEQNGQPIE
IERLLEPGYVEVDAVIPYSRSLDDSYTNKVLVLTREREKGNRIPAEYLGF
ETFVLTNSKKKRDRLLRLHYDENEETEFKNRNLNDTRYISRFFANFIREH
LKFAESDDKQKVYTVNGRVTAHLRSRWEFNKNREESDLHHAVDAVIVACT
TPSDIAKVTAFYQRREQNKELAKKTEPHFPQPWPHFADELRARLSKHPKE
SIKALNLGNYDDQKLESLQPVFVSRMPKRSVTGAAHQETLRRYVGIDERS
GKIQTVVKTKLSEIKLDASGHFPMYGKESDPRTYEAIRQRLLDPKKAFQE
PLYKPKKNGEPGPVIRTVKIIDTKNQVIPLNDGKTVAYNSNIVRVDVFEK
DGKYYCVPVYTMDIMKGILPNKAIEPNKPYSEWKEMTEDYTFRFSLYPND
LIRIELPREKTVKTAAGEEINVKDVFVYYKTIDSANGGLELISHDHRFSL
RGVGSRTLKRFEKYQVDVLGNIYKVRGEKRVGLASSAHSKPG
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8jtj Cryo-EM structure of GeoCas9-sgRNA-DNA ternary complex
Resolution3.08 Å
Binding residue
(original residue number in PDB)		N130 R131 S141 Y181 R248 K267 R269 K315 I317 K374 T416 K417 F418 Y668 Q817 E818 T819 K994 N1020 R1035 G1036 V1037 G1038
Binding residue
(residue number reindexed from 1)		N130 R131 S137 Y177 R244 K263 R265 K308 I310 K362 T404 K405 F406 Y638 Q787 E788 T789 K960 N986 R1001 G1002 V1003 G1004
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0043571 maintenance of CRISPR repeat elements
GO:0051607 defense response to virus

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8jtj, PDBe:8jtj, PDBj:8jtj
PDBsum8jtj
PubMed
UniProtA0A150MP45

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