Structure of PDB 8jpx Chain A Binding Site BS02

Receptor Information
>8jpx Chain A (length=770) Species: 186497 (Pyrococcus furiosus DSM 3638) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKAIVVINLVKINKKIIPDKIYVYRLFNDPEEELQKEGYSIYRLAYENVG
IVIDPENLIIATTKELEYEGEFIPEGEISFSELRNDYQSKLVLRLLKENG
IGEYELSKLLRKFRKPKTFGDYKVIPSVEMSVIKHDEDFYLVIHIIHQIQ
SMKTLWELVNKDPKELEEFLMTHKENLMLKDIASPLKTVYKPCFEEYTKK
PKLDHNQEIVKYWYNYHIERYWNTPEAKLEFYRKFGQVDLKQPAILAKFA
SKIKKNKNYKIYLLPQLVVPTYNAEQLESDVAKEILEYTKLMPEERKELL
ENILAEVDSDIIDKSLSEIEVEKIAQELENKIRVRDDKGNSVPISQLNVQ
KSQLLLWTNYSRKYPVILPYEVPEKFRKIREIPMFIILDSGLLADIQNFA
TNEFRELVKSMYYSLAKKYNSLAKKARSTNEIGLPFLDFRGKEKVITEDL
NSDKGIIEVVEQVSSFMKGKELGLAFIAARNKLSSEKFEEIKRRLFNLNV
ISQVVNEDTLKNKRDKYDRNRLDLFVRHNLLFQVLSKLGVKYYVLDYRFN
YDYIIGIDVAPMKRSEGYIGGSAVMFDSQGYIRKIVPIKIGEQRGESVDM
NEFFKEMVDKFKEFNIKLDNKKILLLRDGRITNNEEEGLKYISEMFDIEV
VTMDVIKNHPVRAFANMKMYFNLGGAIYLIPHKLKQAKGTPIPIKLAKKR
IIKNGKVEKQSITRQDVLDIFILTRLNYGSISADMRLPAPVHYAHKFANA
IRNEWKIKEEFLAEGFLYFV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8jpx Molecular mechanism for target recognition, dimerization, and activation of Pyrococcus furiosus Argonautre
Resolution2.9 Å
Binding residue
(original residue number in PDB)		Y42 Y46 N273 A274 K283 S352 Q353 L356 Y364 F525 H528 D558 P561 I656 K657 N658 K685 S732 H745
Binding residue
(residue number reindexed from 1)		Y42 Y46 N273 A274 K283 S352 Q353 L356 Y364 F525 H528 D558 P561 I656 K657 N658 K685 S732 H745
Enzymatic activity
Enzyme Commision number 3.1.24.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004520 DNA endonuclease activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006259 DNA metabolic process
GO:0044355 clearance of foreign intracellular DNA

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Molecular Function
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Biological Process
External links
PDB RCSB:8jpx, PDBe:8jpx, PDBj:8jpx
PDBsum8jpx
PubMed38295801
UniProtQ8U3D2|AGO_PYRFU Protein argonaute (Gene Name=ago)

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