Structure of PDB 8jh2 Chain A Binding Site BS02

Receptor Information
>8jh2 Chain A (length=1411) Species: 460519 (Komagataella phaffii) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SQFPYSSAPLRSVKEVQFGLLSPEEIRAISVVKIEYPEIMDESRQRPREG
GLNDPKLGSIDRNFKCQTCGEGMAECPGHFGHMELAKPVFHIGFIPKIKK
VCECICMNCGKLLLDETNPTMAQAIRIRDPKKRFNAVWQLCKTKMVCEAD
APSRGGCGNTQPVVRKDGMKLWGTWKKSRDAQPERKLLTPGEILNVFKHI
SPEDCFRLGFNEDYARPEWMIITVLPVPPPQVRPSIAMDETTQGQDDLTH
KLSDILKANINVQKLEMDGSPQHIINEVEQLLQFHVATYMDNDIAGQPQA
LQKSGRPVKAIRARLKGKEGRLRGNLMGKRVDFSARTVISGDPNLELDQV
GVPISIAKTLSYPETVTQYNIHRLTEYVRNGPNEHPGAKYVIRDNGDRID
LRYHKRAGDIVLQYGWKVERHLMDDDPVLFNRQPSLHKMSMMAHRVKVMP
YSTFRLNLSVTSPYNADFDGDEMNLHVPQSEETRAELSQLCAVPLQIVSP
QSNKPVMGIVQDTLCGVRKMTLRDTFIEYEQVMNMLFWVPSWDGVVPQPA
ILKPKPLWTGKQLLSIAIPSGIHLQRTDGGNSLLSPKDNGMLIVDGKVMF
GVVDKKTVGSGGGGLIHTVMREKGPKICAELFGNIQKVVNYWLLHNGFSI
GIGDAIADASTMKEITHAISSAKEQVQEIIYKAQHNELELKPGMTLRESF
EGEVSRTLNDARDSAGRSAEMNLKDLNNVKQMVSAGSKGSFINIAQMSAC
VGQQMVEGKRIAFGFADRSLPHFTKDDFSPESKGFVENSYLRGLTPQEFF
FHAMAGREGLIDTAVKTAETGYIQRRLVKALEDIMVHYDGTTRNSLGDII
QFLYGEDGLDGTQVERQTIDTIPGSDKAFHKRYYVDLMDEKNSIKPDVIE
YAADILGDVELQKELNSEYEQLVSDRKFLREIVFVNGDHNWPLPVNLRRI
IQNAQQIFHLDRAKASDLTIPEIIHGVRDLCKKLFVLRGENELIKEAQQN
ATSLFQCLVRARLATRRILEEFRLNRDAFEWVLGTIEAQFQRSLVHPGEM
VGVIAAQSIGEPATQMNVTLGVPRLKEILNVAKNIKTPALTVYLDREIAL
DIEKAKVIQSSIEYTTLKNVTSATEIYYDPDPTSTVIEEDFDTVEAYFSQ
SPWLLRLELDRARMLDKQLTMNQVADKISEVFSDDLFVMWSEDNADKLII
RCRVIEEDQMLKRIEAHMLDLIALRGIPGISKVYMVKHKVSVPDESGEYK
NEELWALETDGINLAEVMAVPGVDSSRTYSNSFVEILSVLGIEATRSSLY
KEILNVIAFDGSYVNYRHMALLVDVMTSRGYLMAITRHGINRADTGALMR
CSFEETVEILFEAGAAAELDDCRGVSENVMLGQLAPMGTGAFDVMIDEKL
LTSLPADYAPT
Ligand information
>8jh2 Chain T (length=127) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
atcagaatcccggtgccgaggccgctcaattggtcgtagacagctctagc
accgcttaaacgcacgtacgcgctgtcccccgcgttttaaccgccaaggg
gattacacccaagacaccaggcacgag
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8jh2 Cryo-EM structures of RNA polymerase II-nucleosome complexes rewrapping transcribed DNA
Resolution5.7 Å
Binding residue
(original residue number in PDB)		K318 K331 K333 R345 Q448 P449 T832 A833 R1389
Binding residue
(residue number reindexed from 1)		K303 K316 K318 R330 Q433 P434 T817 A818 R1337
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0001055 RNA polymerase II activity
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0005665 RNA polymerase II, core complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8jh2, PDBe:8jh2, PDBj:8jh2
PDBsum8jh2
PubMed37981206
UniProtC4R4Y0

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