Structure of PDB 8j8f Chain A Binding Site BS02

Receptor Information
>8j8f Chain A (length=1005) Species: 10244 (Monkeypox virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GMDVRCINWFESHGENRFLYLKSRCRNGETVFIRFPHYFYYVVTDEIYQS
LSPPPFNARPMGKMRTIDIDETISYNLDIKDRKCSVADMWLIEEPKKRSI
QNATMDEFFNISWFYISNGISPDGCYSLDEQYLTKINNGCYHCDDPRNCF
AKEIPRFDIPRSYLFLDIECHFDKKFPSVFINPISHTSYCYIDLSGKRLL
FTLINEEMLTEQEIQEAVDRGCLRIQSLMEMDYERELVLCSEIVLLRIAK
QLLELTFDYVVTFNGHNFDLRYITNRLELLTGEKIIFRSPDKKEAVHLCI
YERNQSSHKGVCGMANTTFHVNNNNGTIFFDLYSFIQKSEKLDSYKLDSI
SKNAFSCMGKVLNRGVREMTFIGDDTTDAKGKADTFAKVLTTGNYVTVDE
DIICKVIRKDILENGFKVVLSCPTLPNDIYKLSFGKDDIDLAQMYKDYNL
NIALDMARYCIHDACLCQYLWEYYGVETKTDAGAATYVLPQSMVFEYRAS
TIIKGPLLKLLLETKTILVRSETKQKFPYEGGKVFAPKQKMFSNNVLIFD
YNSLYPNVCIFGNLSPETLVGVVVSTNRLEEEINNQLLLQKYPPPRYITV
HCEPRLPNLISEIAIFDRSIEGTIPRLLRTFLAERARYKKMLKQATSSTE
KAIYDSMQYTYKIVANSVYGLMGFRNSALYSYASAKSCTSIGRRMILYLE
SVLNGAELSNGMLRFANTLSNPFYMDDRDINPIVKTSLPIDYRFRFRSVY
GDTDSVFTEIDSQDVDKSIEIAKELERLINSRVLFNNFKIEFEAVYKNLI
MQSKKKYTTMKYSASSNSKSVPERINKGTSETRRDVSKFHKNMIKTYKTR
LSEMLSEGRMNSNQVCIDILRSLETDLRSEFDSRSSPLELFMLSRMHHSN
YKSADNPNMYLVTEYNKNNPETIELGERYYFAYICPANVPWTKKLVNIKT
YETIIDRSFKLGSNQRIFYEVYFKRLTSEIVNLLDNKVLCISFFQRMFGS
RPTFY
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8j8f Structural basis of human monkeypox viral DNA replication inhibition by brincidofovir and cidofovir
Resolution2.98 Å
Binding residue
(original residue number in PDB)		R16 F38 F108 H307 K308 R497 S499 T500 Y528 E529 G530 G531 N665 S666 G669 L670 F673 K803 I947 R974 Y1004
Binding residue
(residue number reindexed from 1)		R17 F39 F109 H308 K309 R498 S500 T501 Y529 E530 G531 G532 N666 S667 G670 L671 F674 K804 I948 R975 Y1005
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006310 DNA recombination
GO:0039693 viral DNA genome replication

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8j8f, PDBe:8j8f, PDBj:8j8f
PDBsum8j8f
PubMed38735603
UniProtQ5IXW8

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