Structure of PDB 8izh Chain A Binding Site BS02

Receptor Information
>8izh Chain A (length=223) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVSAAHCYKSGIQVRL
GEDNINVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAASLNSRV
ASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKS
AYPGQITSNMFCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQK
NKPGVYTKVCNYVSWIKQTIASN
Ligand information
Ligand IDAGU
InChIInChI=1S/CH6N4/c2-1(3)5-4/h4H2,(H4,2,3,5)
InChIKeyHAMNKKUPIHEESI-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(=N)(N)NN
CACTVS 3.341NNC(N)=N
ACDLabs 10.04[N@H]=C(N)NN
FormulaC H6 N4
NameAMINOGUANIDINE
ChEMBLCHEMBL225304
DrugBankDB05383
ZINCZINC000008034829
PDB chain8izh Chain A Residue 306 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8izh Structural basis for the binding of famotidine, cimetidine, guanidine, and pimagedine with serine protease.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		I73 Y151 P152
Binding residue
(residue number reindexed from 1)		I55 Y131 P132
Annotation score1
External links
PDB RCSB:8izh, PDBe:8izh, PDBj:8izh
PDBsum8izh
PubMed39216203
UniProtP00760|TRY1_BOVIN Serine protease 1 (Gene Name=PRSS1)

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