Structure of PDB 8ir3 Chain A Binding Site BS02

Receptor Information
>8ir3 Chain A (length=165) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ELRIRKLCLNICVGESGDRLTRAAKVLEQLTGQTPVFSKARYTVRSFGIR
RNEKIAVHCTVRGAKAEEILEKGLKVREYELRKNNFSDTGNFGFGIQEHI
DLGIKYDPSIGIYGLDFYVVLGRPGFSIADKKRRTGCIGAKHRISKEEAM
RWFQQKYDGIILPGK
Ligand information
>8ir3 Chain 5 (length=120) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaa
gcuaagcagggucgggccugguuaguacuuggaugggagaccgccuggga
auaccgggugcuguaggcuu
<<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..
>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>..
..>>>>>>>>>>>>>>>>..
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8ir3 Visualizing the nucleoplasmic maturation of human pre-60S ribosomal particles.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		Q46 T47 V49 T73 R75 G138 I141 D143 R147 H155
Binding residue
(residue number reindexed from 1)		Q33 T34 V36 T60 R62 G125 I128 D130 R134 H142
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0008097 5S rRNA binding
GO:0019843 rRNA binding
GO:0031625 ubiquitin protein ligase binding
GO:1990948 ubiquitin ligase inhibitor activity
Biological Process
GO:0000027 ribosomal large subunit assembly
GO:0002181 cytoplasmic translation
GO:0006364 rRNA processing
GO:0006412 translation
GO:0006605 protein targeting
GO:0010628 positive regulation of gene expression
GO:0032092 positive regulation of protein binding
GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0034504 protein localization to nucleus
GO:0042273 ribosomal large subunit biogenesis
GO:0050821 protein stabilization
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1901798 positive regulation of signal transduction by p53 class mediator
GO:1904667 negative regulation of ubiquitin protein ligase activity
GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process
GO:2000435 negative regulation of protein neddylation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0016020 membrane
GO:0022625 cytosolic large ribosomal subunit
GO:0022626 cytosolic ribosome
GO:0032991 protein-containing complex
GO:0070062 extracellular exosome
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ir3, PDBe:8ir3, PDBj:8ir3
PDBsum8ir3
PubMed37491604
UniProtP62913|RL11_HUMAN Large ribosomal subunit protein uL5 (Gene Name=RPL11)

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