Structure of PDB 8ikz Chain A Binding Site BS02

Receptor Information
>8ikz Chain A (length=568) Species: 3702 (Arabidopsis thaliana) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SVTADPSPPTNKLNKYSSRITEPKSQGGSQAILHGVGLSDDDLLKPQIGI
SSVWYEGNTCNMHLLKLSEAVKEGVENAGMVGFRFNTIGVSDAISMGTRG
MCFSLQSRDLIADSIETVMSAQWYDGNISIPGCDKNMPGTIMAMGRLNRP
GIMVYGGTIKPGHFQDKTYDIVSAFQSYGEFVSGSISDEQRKTVLHHSCP
GAGACGGMYTANTMASAIEAMGMSLPYSSSIPAEDPLKLDECRLAGKYLL
ELLKMDLKPRDIITPKSLRNAMVSVMALGGSTNAVLHLIAIARSVGLELT
LDDFQKVSDAVPFLADLKPSGKYVMEDIHKIGGTPAVLRYLLELGLMDGD
CMTVTGQTLAQNLENVPSLTEGQEIIRPLSNPIKETGHIQILRGDLAPDG
SVAKITGKEGLYFSGPALVFEGEESMLAAISADPMSFKGTVVVIRGEGPK
GGPGMPEMLTPTSAIMGAGLGKECALLTDGRFSGGSHGFWVGHICPEAQE
GGPIGLIKNGDIITIDIGKKRIDTQVSPEEMNDRRKKWTAPAYKVNRGVL
YKYIKNVQSASDGCVTDE
Ligand information
Ligand IDFES
InChIInChI=1S/2Fe.2S
InChIKeyNIXDOXVAJZFRNF-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04[Fe]1S[Fe]S1
CACTVS 3.341
OpenEye OEToolkits 1.5.0		S1[Fe]S[Fe]1
FormulaFe2 S2
NameFE2/S2 (INORGANIC) CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain8ikz Chain A Residue 604 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8ikz The mutant structure of DHAD
Resolution1.75 Å
Binding residue
(original residue number in PDB)		C66 A99 C139 D140 C211
Binding residue
(residue number reindexed from 1)		C60 A93 C133 D134 C205
Annotation score1
Enzymatic activity
Enzyme Commision number 4.2.1.9: dihydroxy-acid dehydratase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004160 dihydroxy-acid dehydratase activity
GO:0005507 copper ion binding
GO:0016829 lyase activity
GO:0016836 hydro-lyase activity
GO:0046872 metal ion binding
GO:0051537 2 iron, 2 sulfur cluster binding
Biological Process
GO:0008652 amino acid biosynthetic process
GO:0009082 branched-chain amino acid biosynthetic process
GO:0009097 isoleucine biosynthetic process
GO:0009099 L-valine biosynthetic process
GO:0009553 embryo sac development
GO:0009555 pollen development
GO:0009651 response to salt stress
GO:0048364 root development
Cellular Component
GO:0005829 cytosol
GO:0009507 chloroplast
GO:0009536 plastid
GO:0009570 chloroplast stroma

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ikz, PDBe:8ikz, PDBj:8ikz
PDBsum8ikz
PubMed
UniProtQ9LIR4|ILVD_ARATH Dihydroxy-acid dehydratase, chloroplastic (Gene Name=DHAD)

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