Structure of PDB 8ikm Chain A Binding Site BS02

Receptor Information
>8ikm Chain A (length=233) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSG
ECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDV
RSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCP
NSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPE
PDCRKVTCGGNGLGCGFAFCRECKEAYHEGECS
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8ikm Chain A Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8ikm Additional feedforward mechanism of Parkin activation via binding of phospho-UBL and RING0 in trans.
Resolution1.92 Å
Binding residue
(original residue number in PDB)		C166 C169 C196 C201
Binding residue
(residue number reindexed from 1)		C22 C25 C52 C57
Annotation score4
External links
PDB RCSB:8ikm, PDBe:8ikm, PDBj:8ikm
PDBsum8ikm
PubMed39221915
UniProtO60260|PRKN_HUMAN E3 ubiquitin-protein ligase parkin (Gene Name=PRKN)

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