Structure of PDB 8iht Chain A Binding Site BS02

Receptor Information
>8iht Chain A (length=121) Species: 8355 (Xenopus laevis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ARTKQTARKSTGGKAPRKQLATKAPHRYRPGTVALREIRRYQKSTELLIR
KLPFQRLVREIAQDFKTDLRFQSSAVMALQEASEAYLVALFEDTNLAAIH
AKRVTIMPKDIQLARRIRGER
Ligand information
>8iht Chain J (length=159) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
caggatgtatatatctgacacgtgcctggagactagggagtaatcccctt
ggcggttaaaacgcgggggacagcgcgtacgtgcgtttaagcggtgctag
agctgtctacgaccaattgagcggcctcggcaccgggattctccagggcg
gccagtaag
Receptor-Ligand Complex Structure
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PDB8iht Structural basis for nucleosome binding and catalysis by the yeast Rpd3S/HDAC holoenzyme.
Resolution3.72 Å
Binding residue
(original residue number in PDB)		H39 R40 Y41 V46 R49 R63 K64 L65 P66 R83
Binding residue
(residue number reindexed from 1)		H26 R27 Y28 V33 R36 R50 K51 L52 P53 R70
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0030527 structural constituent of chromatin
GO:0046982 protein heterodimerization activity
Cellular Component
GO:0000786 nucleosome
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome

View graph for
Molecular Function
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Cellular Component
External links
PDB RCSB:8iht, PDBe:8iht, PDBj:8iht
PDBsum8iht
PubMed37845487
UniProtP84233|H32_XENLA Histone H3.2

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