Structure of PDB 8idf Chain A Binding Site BS02

Receptor Information

>8idf Chain A (length=459) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

DVESLPRGGFRCSLCHVTTANRPSLDAHLGGRKHRHLVELRAARKAQGLR
SVFVSGFPRDVDSAQLSEYFLAFGPVASVVMDKDKGVFAIVEMGDVGARE
AVLSQSQHSLGGHRLRVRPREQKEFQSPDSHQLAKALAEAADVGAQMIKL
VGLRELSEAERQLRSLVVALMQEVFTEFFPGCVVHPFGSSINSFDVHGCD
LALFLDLGAAMLELVGSILRGCVPGVYRVQTVPSARRPVVKFAHRPSGLH
GDVSLSNRLALHNSRFLSLASELDGRVRPLVYTLRAWAQGRGLSGSGPLL
SNYALTLLVIYFLQTRDPPVLPTVSQLTQKAGEGEQVEVDGWDCSFPRDA
SRLEPSINVEPLSSLLAQFFSAVSSWDLRGSLLSLREGQALEGLRLGPLN
LQDPFDLSHNVAANVTSRVAGRLQNCCRAAANYARSLQYQRRSSRGRDWG
LLPLLQPSS

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

8idf Chain A Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8idf Mechanism of U6 snRNA oligouridylation by human TUT1.
Resolution	3.7 Å
Binding residue (original residue number in PDB)	C21 H34 H40
Binding residue (residue number reindexed from 1)	C15 H28 H34
Annotation score	1

Enzymatic activity

Enzyme Commision number

2.7.7.19: polynucleotide adenylyltransferase.
2.7.7.52: RNA uridylyltransferase.

Gene Ontology

	Molecular Function
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0008270	zinc ion binding

View graph for
Molecular Function

External links

PDB	RCSB:8idf, PDBe:8idf, PDBj:8idf
PDBsum	8idf
PubMed	37563152
UniProt	Q9H6E5\|STPAP_HUMAN Speckle targeted PIP5K1A-regulated poly(A) polymerase (Gene Name=TUT1)

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